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NCT00001642 · ClinicalTrials.gov registry record
Positional Cloning of the Gene(s) Responsible for Alagille Syndrome
A clinical trial, sponsored by National Human Genome Research Institute (NHGRI).
- Completed
- Registry status
- 225
- Enrollment target
NCT00001642: Completed study, sponsored by National Human Genome Research Institute (NHGRI).
NCT00001642 is a clinical trial that has completed, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 225 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001642 has completed, sponsored by National Human Genome Research Institute (NHGRI).
- COMPLETED
- Registry status
- 225 participants
- Enrollment target
Study Summary
The goal of the project is to identify and clone the gene(s) responsible for the Alagille Syndrome (AGS) by a positional cloning approach. The first step towards this goal is to define the smallest genomic candidate region for AGS at 20p12 and to begin to identify genes within this region which are, by definition, candidate genes for the disease. In a collaborative effort with clinician-investigators studying the Alagille syndrome, metaphase chromosomes and genomic DNA from affected individuals will be studied for subchromosomal deletions and for mutations in the candidate genes. Characterization of genes involved in Alagille syndrome could provide important insight into the pathophysiology of the disease, the development of normal liver and treatment of this disease. Recently, we and others found that mutations in Jagged1, a Notch1 receptor are responsible for Alagille Syndrome.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 225 participants |
| Start Date | 1997-05 |
| Est. Completion | 2000-03 |
What the finished NCT00001642 record still lists
NCT00001642 is an observational study that tracks outcomes without assigning an intervention. The registered 225 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00001642 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00001642 about?
NCT00001642 is a clinical study titled "Positional Cloning of the Gene(s) Responsible for Alagille Syndrome". The goal of the project is to identify and clone the gene(s) responsible for the Alagille Syndrome (AGS) by a positional cloning approach. The first step towards this goal is to define the smallest genomic candidate region for AGS at 20p12 and to begin to identify genes within this region which are,...
What is the current status of trial NCT00001642?
This trial is currently completed. The enrollment target is 225 participants. The study started on 1997-05. Estimated completion is 2000-03.
Who is sponsoring clinical trial NCT00001642?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
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