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NCT00001485 · ClinicalTrials.gov registry record
Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder
A clinical trial of Seasonal Affective Disorder, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 116
- Enrollment target
- 1
- Study location
NCT00001485 is a study of Seasonal Affective Disorder that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 116 participants, above the 45-participant average among 3 other Seasonal Affective Disorder trials with a reported enrollment target (158% higher). The trial reports 1 study location across 1 state.
The verdict
NCT00001485, a study of Seasonal Affective Disorder, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 116 participants
- Enrollment target
- 1
- Study location
Study Summary
As the seasons change during the course of the year, many animals show major changes in their behavior and physiology. Many of these changes are triggered by changes in the length of time each night that the pineal gland produces the hormone melatonin. Melatonin is produced for a longer time in winter when nights are long, than in summer when nights are short. Some researchers believe that melatonin may play a similar role in how season effects mood of patients with seasonal affective disorder. Seasonal affective disorder (SAD) or mood disorder with seasonal pattern is a condition where the normal biorhythm is disturbed during a season, especially autumn-winter. Patients may begin experiencing or experience worsening of depressive symptoms. Patients complain of being constantly tired, craving sugary foods, overeating, and over sleeping. Researchers have collected some preliminary data showing that the duration of nighttime melatonin secretion increases in winter and decreases in summer in healthy women, but not in healthy men. However, men diagnosed with SAD have shown longer duration of melatonin secretion in the winter, similar to the duration seen in healthy women. If these early findings are confirmed it may explain why SAD is more common in women than in men. The purpose of this study is to continue researching the differences in melatonin secretion over the seasons in healthy men and women, and to determine how these findings may apply to patients with SAD.
Conditions Studied
Study Locations (1)
Maryland
- National Institute of Mental Health (NIMH) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 116 participants |
| Start Date | 1995-06 |
| Est. Completion | 2000-04 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00001485
The ClinicalTrials.gov registry entry for NCT00001485 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 116 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 45-participant average among 3 other Seasonal Affective Disorder trials with a reported enrollment target (158% higher). The listed sponsor is National Institute of Mental Health (NIMH), which has 343 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Seasonal Affective Disorder appearing as the primary indexed condition, and to 0 interventions.
NCT00001485 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00001485 about?
NCT00001485 is a clinical study titled "Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder". As the seasons change during the course of the year, many animals show major changes in their behavior and physiology. Many of these changes are triggered by changes in the length of time each night that the pineal gland produces the hormone melatonin. Melatonin is produced for a longer time in wint...
What is the current status of trial NCT00001485?
This trial is currently completed. The enrollment target is 116 participants. The study started on 1995-06. Estimated completion is 2000-04.
What conditions does trial NCT00001485 study?
This clinical trial studies the following conditions: Seasonal Affective Disorder.
Who is sponsoring clinical trial NCT00001485?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00001485 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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