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NCT00001308 · ClinicalTrials.gov registry record
Central Mechanisms in Speech Motor Control Studied With H215O PET
A clinical trial, sponsored by National Institute on Deafness and Other Communication Disorders (NIDCD).
- Terminated
- Registry status
- 1,163
- Enrollment target
NCT00001308 is a clinical trial that was terminated before completion, run by National Institute on Deafness and Other Communication Disorders (NIDCD). The registered enrollment target is 1,163 participants.
The verdict
NCT00001308 was terminated before completion, sponsored by National Institute on Deafness and Other Communication Disorders (NIDCD).
- TERMINATED
- Registry status
- 1,163 participants
- Enrollment target
Study Summary
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. Radioactive water H215O in PET scans permits good visualization of areas of the brain related to speech. Most of the PET scan studies conducted have concentrated on learning about how language is formed and decoded. Few studies have been conducted on speech production. This study aims to use radioactive water (H215O) and Positron Emission Tomography (PET scan) to measure blood flow to different areas of the brain in order to better understand the mechanisms involved in speech motor control. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive chemicals (H215O) and PET scans to observe what areas of the brain are receiving more blood flow. Researchers will ask patients to perform tasks that will affect speech, voice, and language. At the same time patients will undergo a PET scan. The tasks are designed to help researchers observe the blood flow to brain areas associated with voicebox (laryngeal) functions, movement of muscles in the jaw, tongue, and mouth, and other aspects of motor speech. Special studies will be conducted to evaluate how certain therapies and tasks can draw out symptoms in illnesses in which speech and language are affected. Results of these tests will be used in other studies to evaluate the neurologic mechanisms of diseases like Tourette's syndrome and parkinson's disea
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,163 participants |
| Start Date | 1992-04-28 |
| Est. Completion | 2016-10-06 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00001308
The ClinicalTrials.gov registry entry for NCT00001308 describes a study currently listed as terminated, categorized as an unspecified phase. The registered enrollment target is 1,163 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute on Deafness and Other Communication Disorders (NIDCD), which has 34 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00001308 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00001308 about?
NCT00001308 is a clinical study titled "Central Mechanisms in Speech Motor Control Studied With H215O PET". Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of normal individuals and patients with neurologic illnesses without phys...
What is the current status of trial NCT00001308?
This trial is currently terminated. The enrollment target is 1,163 participants. The study started on 1992-04-28. Estimated completion is 2016-10-06.
Who is sponsoring clinical trial NCT00001308?
This trial is sponsored by National Institute on Deafness and Other Communication Disorders (NIDCD), which has 34 total clinical trials registered on ClinicalTrials.gov.
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