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NCT00001008 · ClinicalTrials.gov registry record · NA

A Study of Azidothymidine Plus Methadone in Patients With AIDS and AIDS Related Complex (ARC)

A NA study of HIV Infections, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

Completed
Registry status
NA
Development phase
18
Enrollment target
1
Study location

NCT00001008: Completed NA study of HIV Infections, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

NCT00001008 is a NA study of HIV Infections that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 18 participants, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00001008, a NA study of HIV Infections, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

COMPLETED
Registry status
NA
Development phase
18 participants
Enrollment target
1
Study location

Study Summary

To determine if methadone treatment will affect the blood levels of zidovudine (AZT) in patients with AIDS or AIDS-related complex (ARC) who are receiving oral AZT and methadone therapy. In addition, the blood levels of methadone both before and during AZT treatment will be studied, and patients receiving daily oral methadone treatment will be evaluated for signs of narcotic withdrawal during treatment with AZT. The number of deaths due to AIDS in high-risk populations continues to increase. Nationwide approximately 25 percent of AIDS patients are intravenous (IV) drug abusers, and it is very likely that an increasingly larger number of AIDS patients receiving AZT therapy will have had a history of IV drug abuse. The major chemical treatment for IV drug abuse is daily methadone maintenance therapy, and IV drug abusers who are HIV positive represent a large number of patients who will undergo long-term treatment with both methadone and AZT. Therefore, the study of potential drug interactions is essential.

Conditions Studied

HIV Infections

Interventions

  • DRUG Zidovudine
  • DRUG Methadone hydrochloride

Study Locations (1)

New York

  • Montefiore Med Ctr / Bronx Municipal Hosp - The Bronx

Trial Details

FieldValue
Enrollment Target 18 participants
Phase NA
National Institute of Allergy and Infectious Diseases (NIAID)

2,006 total trials

What the finished NCT00001008 record still lists

NCT00001008 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (96% lower).

The record links to 1 condition, with HIV Infections appearing as the primary indexed condition, and to 2 interventions - of which Zidovudine is the first listed.

NCT00001008 reports a single indexed study location in New York.

Frequently Asked Questions

What is clinical trial NCT00001008 about?

NCT00001008 is a clinical study titled "A Study of Azidothymidine Plus Methadone in Patients With AIDS and AIDS Related Complex (ARC)". To determine if methadone treatment will affect the blood levels of zidovudine (AZT) in patients with AIDS or AIDS-related complex (ARC) who are receiving oral AZT and methadone therapy. In addition, the blood levels of methadone both before and during AZT treatment will be studied, and patients rec...

What is the current status of trial NCT00001008?

This trial is currently completed. It is a NA study. The enrollment target is 18 participants.

What conditions does trial NCT00001008 study?

This clinical trial studies the following conditions: HIV Infections.

What interventions are being tested in trial NCT00001008?

The interventions under investigation include: Zidovudine (DRUG), Methadone hydrochloride (DRUG).

Who is sponsoring clinical trial NCT00001008?

This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00001008 being conducted?

This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for HIV Infections

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00001008's enrollment target sits among peer trials

18 504th of 542 higher than 31 of 542 other HIV Infections trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT00001008, the US trial registry maintained by the National Library of Medicine. NCT00001008 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.