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NCT00000457 · ClinicalTrials.gov registry record · Phase 2
Pharmacologic Relapse Prevention for Alcoholic Smokers
A Phase 2 study, sponsored by Mayo Clinic.
- Completed
- Registry status
- Phase 2
- Development phase
- 195
- Enrollment target
NCT00000457: Completed Phase 2 study, sponsored by Mayo Clinic.
NCT00000457 is a Phase 2 study that has completed, run by Mayo Clinic. The registered enrollment target is 195 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (47% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00000457, a Phase 2 study, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 195 participants
- Enrollment target
Study Summary
This study will compare the long-term use of bupropion (Wellbutrin) and placebo for reducing the rate of smoking relapse in recovering alcoholics who achieved initial abstinence from smoking with nicotine patch therapy. The study will also determine the cessation rate in the 8th week of treatment among recovering alcoholics using a nicotine patch. The patch dose is projected to serve as a 100-percent replacement.
Primary Outcome
Determine if long-term use of bupropion will reduce the rate of relapse to smoking compared to placebo in recovering alcoholics who achieved initial abstinence from smoking with nicotine patch therapy projected to achieve 100% replacement.
Interventions
- DRUG Placebo
- DRUG bupropion (Wellbutrin)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 195 participants |
| Start Date | 1998-06 |
| Est. Completion | 2007-08 |
| Phase | Phase 2 |
What the finished NCT00000457 record still lists
NCT00000457 is an interventional study that assigns participants to a tested intervention. The registered 195 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (47% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00000457 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00000457 about?
NCT00000457 is a clinical study titled "Pharmacologic Relapse Prevention for Alcoholic Smokers". This study will compare the long-term use of bupropion (Wellbutrin) and placebo for reducing the rate of smoking relapse in recovering alcoholics who achieved initial abstinence from smoking with nicotine patch therapy. The study will also determine the cessation rate in the 8th week of treatment am...
What is the current status of trial NCT00000457?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 195 participants. The study started on 1998-06. Estimated completion is 2007-08.
What interventions are being tested in trial NCT00000457?
The interventions under investigation include: Placebo (DRUG), bupropion (Wellbutrin) (DRUG).
Who is sponsoring clinical trial NCT00000457?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00000457's enrollment target sits among peer trials
195 350th of 2000 higher than 1,649 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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