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Osteogenesis Imperfecta clinical trials
3 of 14 indexed Osteogenesis Imperfecta trials are currently recruiting.
14 US clinical trials · 3 currently recruiting
Osteogenesis Imperfecta is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Baylor College of Medicine, running 5 of these trials.
The research picture
Osteogenesis Imperfecta has 14 registered US clinical trials, 3 of them open to new participants right now, about 21% of the total.
- 3
- recruiting participants now
- 21%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Baylor College of Medicine
Active & Recent Trials
14 total, page 1 of 1
BBD Longitudinal Study of Osteogenesis Imperfecta
Baylor College of Medicine
NCT02432625
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
Amgen
NCT05972551
Effects of Bisphosphonates on OI-Related Hearing Loss
Hospital for Special Surgery, New York
NCT04152551
Setrusumab vs Placebo for Osteogenesis Imperfecta
Ultragenyx Pharmaceutical
NCT05125809
Dental Malocclusion and Craniofacial Development in OI
Baylor College of Medicine
NCT02934451
Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta
Ultragenyx Pharmaceutical
NCT05768854
Clear Aligners for the Treatment of Dental Malocclusion in OI
Baylor College of Medicine
NCT04815564
Urinary Biomarkers of OI Pathobiology
Baylor College of Medicine
NCT02531087
Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708
Baylor College of Medicine
NCT05317637
Evaluation and Treatment of Patients With Connective Tissue Disease
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00076830
Safety and Efficacy of Risedronate in the Treatment of Osteogenesis Imperfecta in Children
Warner Chilcott
NCT00106028
Evaluation and Intervention for the Effects of Osteogenesis Imperfecta
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00001594
Growth Hormone Therapy in Osteogenesis Imperfecta
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00001305
Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfecta
Ultragenyx Pharmaceutical
NCT01417091
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 4 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Osteogenesis Imperfecta Trial Landscape
14 indexed Osteogenesis Imperfecta studies · 3 recruiting (21%).
Phase mix: 5 late (III/IV) vs 2 early (I/II).
Top sponsor: Baylor College of Medicine (5 trials), 5 others listed. 14 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Osteogenesis Imperfecta?
PlainTrial tracks 14 US clinical trials for Osteogenesis Imperfecta, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Osteogenesis Imperfecta?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.