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ClinicalTrials.gov 3 recruiting now official registry

Osteogenesis Imperfecta clinical trials

3 of 14 indexed Osteogenesis Imperfecta trials are currently recruiting.

14 US clinical trials · 3 currently recruiting

Osteogenesis Imperfecta is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Baylor College of Medicine, running 5 of these trials.

The research picture

Osteogenesis Imperfecta has 14 registered US clinical trials, 3 of them open to new participants right now, about 21% of the total.

3
recruiting participants now
21%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
5
top sponsor: Baylor College of Medicine
Phase 22Phase 34Phase 41

Active & Recent Trials

14 total, page 1 of 1

RECRUITING 1,000 participants

BBD Longitudinal Study of Osteogenesis Imperfecta

Baylor College of Medicine

NCT02432625

RECRUITING Phase 3 106 participants

Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

Amgen

NCT05972551

RECRUITING Phase 4 100 participants

Effects of Bisphosphonates on OI-Related Hearing Loss

Hospital for Special Surgery, New York

NCT04152551

ACTIVE NOT RECRUITING Phase 2 183 participants

Setrusumab vs Placebo for Osteogenesis Imperfecta

Ultragenyx Pharmaceutical

NCT05125809

ACTIVE NOT RECRUITING 75 participants

Dental Malocclusion and Craniofacial Development in OI

Baylor College of Medicine

NCT02934451

ACTIVE NOT RECRUITING Phase 3 69 participants

Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta

Ultragenyx Pharmaceutical

NCT05768854

ACTIVE NOT RECRUITING NA 57 participants

Clear Aligners for the Treatment of Dental Malocclusion in OI

Baylor College of Medicine

NCT04815564

ACTIVE NOT RECRUITING 25 participants

Urinary Biomarkers of OI Pathobiology

Baylor College of Medicine

NCT02531087

ACTIVE NOT RECRUITING 18 participants

Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708

Baylor College of Medicine

NCT05317637

COMPLETED 180 participants

Evaluation and Treatment of Patients With Connective Tissue Disease

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00076830

COMPLETED Phase 3 143 participants

Safety and Efficacy of Risedronate in the Treatment of Osteogenesis Imperfecta in Children

Warner Chilcott

NCT00106028

COMPLETED 88 participants

Evaluation and Intervention for the Effects of Osteogenesis Imperfecta

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00001594

COMPLETED Phase 3 42 participants

Growth Hormone Therapy in Osteogenesis Imperfecta

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00001305

COMPLETED Phase 2 10 participants

Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfecta

Ultragenyx Pharmaceutical

NCT01417091

Phase Distribution

PhaseTrial count
Phase 2 2
Phase 3 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Osteogenesis Imperfecta Trial Landscape

14 indexed Osteogenesis Imperfecta studies · 3 recruiting (21%).

Phase mix: 5 late (III/IV) vs 2 early (I/II).

Top sponsor: Baylor College of Medicine (5 trials), 5 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Osteogenesis Imperfecta?

PlainTrial tracks 14 US clinical trials for Osteogenesis Imperfecta, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Osteogenesis Imperfecta?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.