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ClinicalTrials.gov 3 recruiting now early-phase tilt small index

Necrotizing Enterocolitis: early-phase trial registry

3 of 15 indexed Necrotizing Enterocolitis trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,140 of 28,707 conditions by registered trial count.

15 US clinical trials · 3 currently recruiting · #1,140 of 28,707 conditions by registered trial count

Necrotizing Enterocolitis: 15 US clinical trials tracked, 3 recruiting.

Necrotizing Enterocolitis is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Infant Bacterial Therapeutics, running 2 of these trials.

Enrollment posture brief

Registry condition necrotizing-enterocolitis

OPEN 3 | RECR 20% | LATE 1 | EARLY 6 | RANK #1140 | SPON 2

Nearest open-share peer: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive (20% recruiting · 10 trials)

Advanced Lung Non-Small Cell53.3%AIDS26.7%Necrotizing Enterocoliti (th…20%Adult Acute Myeloid Leukemia0%Adult Glioblastoma0%
Open-enrollment share among volume-matched conditions near Necrotizing Enterocolitis

Necrotizing Enterocolitis lists 3 open slots (20% of 15 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Necrotizing Enterocolitis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Necrotizing Enterocolitis is recruiting below its size-band peers.

    3 of 15 indexed trials (20%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Necrotizing Enterocolitis trials is spread across many organizations.

    Infant Bacterial Therapeutics accounts for 2 of 15 trials (13.3%). 13 distinct sponsors appear on at least one study for this condition label.

  3. Typical Necrotizing Enterocolitis enrolment sits around 130 participants.

    Median target enrolment is 130 among the 15 trials that report a genuine target (sentinel values excluded). 6 of those (40%) plan for fewer than 100 participants.

  4. Necrotizing Enterocolitis splits between interventional and observational designs.

    10 interventional and 5 observational studies make up this index (66.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 23Phase 31

Open and recent trials

15 total, page 1 of 1

RECRUITING 450 participants

Early Predictors of Necrotizing Enterocolitis in Neonates

Nationwide Children's Hospital

NCT03210831

RECRUITING NA 200 participants

Early Routine vs. Selective Human Milk Fortification in Extremely Preterm Infants

Crouse Hospital

NCT04284280

RECRUITING Phase 1 36 participants

Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis

Noveome Biotherapeutics, formerly Stemnion

NCT06315738

ACTIVE NOT RECRUITING Phase 3 2,158 participants

IBP-9414 for the Prevention of Necrotizing Enterocolitis - The Connection Study

Infant Bacterial Therapeutics

NCT03978000

ACTIVE NOT RECRUITING 324 participants

RBC Irradiation, Anemia and Gut Injury

Emory University

NCT02741648

ACTIVE NOT RECRUITING 300 participants

A Cohort Study of the Intestinal Microbiota of Premature Infants

University of California, Davis

NCT03717584

ACTIVE NOT RECRUITING Phase 2 78 participants

RIC-NEC Randomized Controlled Trial

The Hospital for Sick Children

NCT05279664

COMPLETED Phase 2 202 participants

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus

University of California, San Francisco

NCT01958320

COMPLETED Phase 1 200 participants

Pharmacokinetic (PK) and Safety Study of Meropenem in Young Infants With Intra-abdominal Infections

The Emmes Company

NCT00621192

COMPLETED NA 130 participants

Comparison of Two Surgical Treatments for Necrotizing Enterocolitis in Human Infants

Yale University

NCT00252681

COMPLETED Phase 2 120 participants

IBP-9414 for the Prevention of Necrotizing Enterocolitis

Infant Bacterial Therapeutics

NCT02472769

COMPLETED 64 participants

Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus

University of Utah

NCT03551600

COMPLETED 52 participants

Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis

University of Utah

NCT01735578

COMPLETED Early Phase 1 40 participants

Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy

Wake Forest University

NCT01306838

COMPLETED NA 29 participants

Collaborative Research Group for Necrotizing Enterocolitis

Washington University School of Medicine

NCT00828451

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 3
Phase 3 1

Named interventions

Most-linked intervention names on Necrotizing Enterocolitis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

IBP-9414 Drug
2 trials
Placebo Drug
2 trials
Near-infrared spectroscopy (NIRS) Procedure
1 trials
primary peritoneal drainage Procedure
1 trials
laparotomy Procedure
1 trials
MicroLipid and fish oil Dietary supplement
1 trials
[5,5,5-2H3]leucine (stable isotope labeled leucine) Biological
1 trials
no pharmacologic treatment of the PDA Other
1 trials

US sites by state

Facility locations filed on Necrotizing Enterocolitis trials. A trial with sites in several states counts in each.

Florida 5 trials
California 5 trials
New York 4 trials
North Carolina 4 trials
Illinois 4 trials
Connecticut 4 trials
Utah 3 trials
Ohio 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Necrotizing Enterocolitis page

15 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Necrotizing Enterocolitis condition card totals 15 registered trials; most-linked intervention IBP-9414; top US site state Florida. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.