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ClinicalTrials.gov 1 recruiting now early-phase tilt small index

Dry Eye Syndrome: early-phase trial registry

1 of 11 indexed Dry Eye Syndrome trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,577 of 28,707 conditions by registered trial count.

11 US clinical trials · 1 currently recruiting · #1,577 of 28,707 conditions by registered trial count

Dry Eye Syndrome: 11 US clinical trials tracked, 1 recruiting.

Dry Eye Syndrome is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Mitotech, running 2 of these trials.

Enrollment posture brief

Registry condition dry-eye-syndrome

OPEN 1 | RECR 9% | LATE 3 | EARLY 5 | RANK #1577 | SPON 2

Nearest open-share peer: Advanced Cancers (9% recruiting · 11 trials)

Acute Pancreatitis81.8%Acute Stroke45.5%Acquired Brain Injury36.4%Acute Lung Injury9.1%Dry Eye Syndrome (this)9%
Open-enrollment share among volume-matched conditions near Dry Eye Syndrome

Dry Eye Syndrome lists 1 open slots (9% of 11 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Dry Eye Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Dry Eye Syndrome is recruiting below its size-band peers.

    1 of 11 indexed trials (9.1%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Dry Eye Syndrome research.

    Mitotech accounts for 2 of 11 trials (18.2%). 10 distinct sponsors appear on at least one study for this condition label.

  3. Most Dry Eye Syndrome trials plan to enrol fewer than 100 people.

    Median target enrolment is 55 among the 11 trials that report a genuine target (sentinel values excluded). 8 of those (72.7%) plan for fewer than 100 participants.

  4. Dry Eye Syndrome research is mostly interventional.

    11 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 22Phase 32Phase 41

Open and recent trials

11 total, page 1 of 1

RECRUITING Phase 1 36 participants

A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE) and Sjogren's Disease (SjD)

AbbVie

NCT06977724

COMPLETED Phase 3 610 participants

Vehicle-Controlled Study of SkQ1 as Treatment for Dry-eye Syndrome

Mitotech

NCT04206020

COMPLETED Phase 3 452 participants

Study of SkQ1 as Treatment for Dry-eye Syndrome

Mitotech

NCT03764735

COMPLETED Phase 2 220 participants

Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment

BRIM Biotechnology

NCT04343287

COMPLETED Phase 2 89 participants

Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Dry Eye

Eyegate Pharmaceuticals

NCT00765804

COMPLETED Phase 1 89 participants

Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease

Senju Pharmaceutical Co.

NCT04139122

COMPLETED NA 55 participants

Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator

Oculeve

NCT02798289

COMPLETED Phase 1 30 participants

Study of ST266 Eye Drops in Treating Dry Eye

Noveome Biotherapeutics, formerly Stemnion

NCT02369861

COMPLETED NA 27 participants

Oral Omega-3 Fatty Acids in the Treatment of Dry Eye Syndrome

Milton S. Hershey Medical Center

NCT01107964

COMPLETED Phase 4 20 participants

Effects of Dry Eye Treatments on the Ocular Surface

Baylor College of Medicine

NCT01797822

COMPLETED NA 20 participants

The Effect of a New Emulsion in Dry Eye Patients on Tear Layer Aberrometry, Contrast Sensitivity, and Reading Ability

Southern California College of Optometry at Marshall B. Ketchum University

NCT01013077

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 2
Phase 3 2
Phase 4 1

Named interventions

Most-linked intervention names on Dry Eye Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
2 trials
New Emulsion, Optive, Soothe Other
1 trials
Soothe, New Emulsion, Optive Other
1 trials
Optive, Soothe, New Emulsion Other
1 trials
Refresh Lubricant Eye Drops Drug
1 trials
ST266 Drug
1 trials
SkQ1 Ophthalmic Solution Drug
1 trials
SkQ1 Vehicle Solution Drug
1 trials

US sites by state

Facility locations filed on Dry Eye Syndrome trials. A trial with sites in several states counts in each.

California 5 trials
Massachusetts 4 trials
Tennessee 3 trials
Texas 2 trials
Indiana 2 trials
Arizona 2 trials
Virginia 1 trials
Pennsylvania 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Dry Eye Syndrome page

11 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 1 Dry Eye Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Mitotech sponsors the most Dry Eye Syndrome trials on record, review their full trial history before evaluating a specific study. See Mitotech's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Dry Eye Syndrome condition card totals 11 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.