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ClinicalTrials.gov 6 recruiting now early-phase tilt small index

Chronic Musculoskeletal Pain: early-phase trial registry

6 of 14 indexed Chronic Musculoskeletal Pain trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,230 of 28,707 conditions by registered trial count.

14 US clinical trials · 6 currently recruiting · #1,230 of 28,707 conditions by registered trial count

Chronic Musculoskeletal Pain: 14 US clinical trials tracked, 6 recruiting.

Chronic Musculoskeletal Pain is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.

Enrollment posture brief

Registry condition chronic-musculoskeletal-pain

OPEN 6 | RECR 43% | LATE 0 | EARLY 1 | RANK #1230 | SPON 6

Nearest open-share peer: Acute Myelogenous Leukemia (AML) (43% recruiting · 7 trials)

Chronic Musculoskeletal (th…43%Acute Respiratory Failure35.7%Adherence, Medication35.7%Acromegaly28.6%Abscess7.1%
Open-enrollment share among volume-matched conditions near Chronic Musculoskeletal Pain

Chronic Musculoskeletal Pain lists 6 open slots (43% of 14 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Chronic Musculoskeletal Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Chronic Musculoskeletal Pain is recruiting below its size-band peers.

    6 of 14 indexed trials (42.9%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Chronic Musculoskeletal Pain research.

    VA Office of Research and Development accounts for 6 of 14 trials (42.9%). 9 distinct sponsors appear on at least one study for this condition label.

  3. Typical Chronic Musculoskeletal Pain enrolment sits around 136 participants.

    Median target enrolment is 136 among the 14 trials that report a genuine target (sentinel values excluded). 6 of those (42.9%) plan for fewer than 100 participants.

  4. Chronic Musculoskeletal Pain research is mostly interventional.

    11 interventional and 3 observational studies make up this index (78.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 21

Open and recent trials

14 total, page 1 of 1

RECRUITING NA 216 participants

Group-Based Psychological Treatments Over Video Conference for Older Veterans With Chronic Pain

VA Office of Research and Development

NCT06004804

RECRUITING NA 180 participants

Stepped-Care Intervention of Music and Imagery to Assess Relief (SCIMITAR) Trial

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT07217821

RECRUITING NA 160 participants

Comparing Single-Session Therapies for Chronic Pain

Mark A. Lumley

NCT07008105

RECRUITING NA 136 participants

The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain

VA Office of Research and Development

NCT05701982

RECRUITING NA 39 participants

This Project is a Three-arm RCT Evaluating Two, Single-session Behavioral Interventions for Adults With Chronic Musculoskeletal Pain (CMP) -- 1) Brief Mindfulness-Oriented Recovery Enhancement (B-MORE) vs. Empowered Relief (ER) -- Relative to the Traditional 8-week Version of MORE.

Florida State University

NCT07193095

RECRUITING NA 10 participants

Pain Disengagement Training (Open Pilot)

Massachusetts General Hospital

NCT06870162

ACTIVE NOT RECRUITING 250 participants

Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation

Stanford University

NCT04994249

COMPLETED 3,726 participants

Assessing Pain, Patient Reported Outcomes and Complementary and Integrative Health

VA Office of Research and Development

NCT05097521

COMPLETED NA 730 participants

Mission Reconnect-Veterans and Their Partners to Manage Pain and PTSD (MR)

VA Office of Research and Development

NCT03593772

COMPLETED NA 104 participants

University of Michigan / Wayne State Chronic Pain Study

Wayne State University

NCT03391661

COMPLETED Phase 2 40 participants

Krill Oil for Pain in Elders

University of Florida

NCT06580912

COMPLETED NA 37 participants

Pilot Testing A Theory-Driven Self-Management Intervention for Chronic Musculoskeletal Pain

Johns Hopkins University

NCT05020470

COMPLETED NA 23 participants

Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD

VA Office of Research and Development

NCT03283163

COMPLETED 9 participants

BRAIN, Symptoms, and Physical Activity in COPD

VA Office of Research and Development

NCT04291131

Phase Distribution

PhaseTrial count
Phase 2 1

Named interventions

Most-linked intervention names on Chronic Musculoskeletal Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Cognitive Behavioral Therapy Behavioral
2 trials
Usual Care Other
2 trials
In-Person Training Other
1 trials
Virtual Auricular Point Acupressure (APA) Device
1 trials
Mixed vegetable oil Dietary supplement
1 trials
Krill oil Drug
1 trials
Combination of practitioner-delivered and self-care CIH therapies (described above) as received in VHA and community practice settings Other
1 trials
Self-care CIH therapies (yoga, Tai Chi/Qigong , meditation) as received in VHA and community practice settings Other
1 trials

US sites by state

Facility locations filed on Chronic Musculoskeletal Pain trials. A trial with sites in several states counts in each.

Massachusetts 4 trials
Michigan 3 trials
Florida 3 trials
California 3 trials
Washington 2 trials
Nevada 1 trials
Maryland 1 trials
Indiana 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Chronic Musculoskeletal Pain page

14 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Musculoskeletal Pain condition card totals 14 registered trials; most-linked intervention Cognitive Behavioral Therapy; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.