Browse All Conditions

Explore 28,964 medical conditions with active and completed U.S. clinical trial data drawn from ClinicalTrials.gov, the U.S. National Institutes of Health public registry. According to ClinicalTrials.gov, the National Institutes of Health public registry maintained by the U.S. National Library of Medicine catalogs more than 500,000 clinical studies across over 220 countries since 1997, with the U.S. Food and Drug Administration Amendments Act (FDAAA) of 2007 requiring registration for most studies of FDA-regulated products. See our methodology for refresh cadence.

PlainTrial's condition directory indexes every disease, disorder, syndrome, and medical condition with at least one clinical study registered on ClinicalTrials.gov. Each entry links to a per-condition profile page showing recruiting trials, completed studies, phase distribution, sponsor mix, and geographic coverage. We use the MeSH-aligned condition names submitted by trial sponsors to the National Library of Medicine, so a condition you find here is the same condition a clinician would search on PubMed or a researcher would tag in a grant application.

Use the alphabetical index to browse the full list, or sort by trial volume to find conditions with the deepest active research pipelines. Conditions with a "Recruiting" count in the third column have at least one trial currently enrolling participants - click through to see locations and eligibility. Conditions with high trial counts but zero recruiting slots usually reflect a maturing pipeline (Phase 3 studies are enrollment-closed) or a condition where standard-of-care has shifted research focus to combination therapies and post-approval surveillance.

The directory is comprehensive but not equally deep across conditions. Rare diseases may show fewer than a handful of trials because patient populations are limited - this is a feature of clinical research, not an indexing gap on our end. Common conditions (cancer subtypes, diabetes, hypertension, depression) show dozens to hundreds of studies because they attract the broadest sponsor investment. Every number on this page comes directly from ClinicalTrials.gov; we do not manually edit counts, and we update from the NLM bulk-export on a regular cadence so what you see reflects the most recent registry state we have ingested.

Breast Cancer1,251Healthy1,096Obesity1,057Prostate Cancer749Depression687Cancer621HIV Infections615Hypertension472Stroke456Non-Small Cell Lung Cancer450
A2,832B1,103C2,954D1,173E990F827G777H1,716I1,113J83K188L1,242M2,127N1,045O826P2,857Q24R1,694S3,019T976U530V511W241X47Y19Z17
Treemap Treemap of 10 categories, sized proportional to value. Breast Cancer - 1,251 Breast Cancer 1,251 Healthy - 1,096 Healthy 1,096 Obesity - 1,057 Obesity 1,057 Prostate Cancer - 749 Prostate Cancer 749 Depression - 687 Depression 687 Cancer - 621 Cancer 621 HIV Infections - 615 HIV Infections 615 Hypertension - 472 Hypertension 472 Stroke - 456 Stroke 456 Non-Small Cell Lung Cancer - 450 Non-Small Cell Lu… 450
Condition Trials
Locally Advanced Unresectable Gastroesophageal Junction Adenocarcinoma 1
Locally Advanced Unresectable HER2-Negative Breast Carcinoma 1
Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma 1
Locally Advanced Unresectable Malignant Solid Neoplasm 1
Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma 1
Locally Advanced Unresectable or Metastatic Solid Tumors 1
Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer 1
Locally Advanced Unresectable Pancreatic Adenocarcinoma 3
Locally Advanced Unresectable Pancreatic Cancer Treated With Chemoradiotherapy 1
Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma 1
Locally Advanced Unresectable Primary Central Chondrosarcoma 1
Locally Advanced Unresectable Soft Tissue Sarcoma 1
Locally Advanced Unresectable Triple-Negative Breast Carcinoma 1
Locally Advanced Unresectable Uveal Melanoma 1
Locally Advanced Ureter Urothelial Carcinoma 7
Locally Advanced Urethral Urothelial Carcinoma 6
Locally Advanced Urothelial Cancer 1
Locally Advanced Urothelial Carcinoma 15
Locally Advanced Uterine Corpus Leiomyosarcoma 1
Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation 1
Locally Advanced/Metastatic HER2 Positive Solid Tumors 1
Locally Advanced/Metastatic Solid Tumors 2
Locally Recurrent Head and Neck Squamous Cell Carcinoma 5
Locally Recurrent Hypopharyngeal Squamous Cell Carcinoma 2
Locally Recurrent Laryngeal Squamous Cell Carcinoma 2
Locally Recurrent or Metastatic Breast Cancer 1
Locally Recurrent or Metastatic Cancer of the Head and Neck 1
Locally Recurrent Oral Cavity Squamous Cell Carcinoma 3
Locally Recurrent Oropharyngeal Squamous Cell Carcinoma 2
Locally Recurrent Prostate Cancer 1
Locally Recurrent Prostate Carcinoma 1
Locally Recurrent Skin Squamous Cell Carcinoma 1
Locally Recurrent/Metastatic Triple Negative Breast Cancer 1
Locked-in Syndrome 5
Locomotion 1
Locomotor Adaptability 1
Locoregional Flap-Based Closure 1
Locoregional Recurrence 1
Locoregionally Recurrent Hormone-receptor Positive Breast Cancer 2
Loeys-Dietz Syndrome 3
Logopenic Progressive Aphasia 6
Logopenic Progressive Aphasia (LPA) 3
Logopenic Variant of Primary Progressive Aphasia (LPA) 2
Logopenic Variant Primary Progressive Aphasia 3
Loneliness 36
Long Bone Fractures 1
Long Bone Segmental Defect 1
Long Coronavirus Disease 2019 (Covid19) 1
Long COVID 51
Long COVID Syndrome 3