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NCT07680153 · ClinicalTrials.gov registry record · Phase 4
Neuromodulation of Mood Switch Circuitry in Bipolar Disorder
A Phase 4 study, sponsored by Weill Medical College of Cornell University.
- Not yet
- Registry status
- Phase 4
- Development phase
- 62
- Enrollment target
NCT07680153 is a Phase 4 study that has not yet begun recruiting, run by Weill Medical College of Cornell University. The registered enrollment target is 62 participants.
The verdict
NCT07680153, a Phase 4 study, has not yet begun recruiting, sponsored by Weill Medical College of Cornell University.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 62 participants
- Enrollment target
Study Summary
This study is exploring a new approach to treating depression in people with bipolar disorder (BD). Investigators are testing whether a non-invasive form of brain stimulation can help us understand depressed-to-euthymic mood shifts and their related brain circuits in BD. Investigators in this study will use a technique called repetitive transcranial magnetic stimulation, or rTMS. It uses non-invasive magnetic pulses delivered to the scalp to stimulate specific areas of the brain. rTMS is already used to treat depression, and investigators are now studying whether it can be made even more effective for people with bipolar disorder by precisely targeting an individualized brain region for each participant. Participants in this study will receive two courses of rTMS, one active and one placebo (called "sham"), in a randomized order so investigators can directly compare the effects. Before treatment, investigators will use brain scans (MRI) to create a personalized map of each participant's brain activity. This lets investigators identify the exact stimulation target most likely to influence the brain circuits involved in BD mood shifts. Investigators will track mood symptoms closely throughout the study to measure what changes. Investigators believe that depression in BD is partly driven by disrupted communication between two brain regions involved in processing what feels important or rewarding. Investigators want to find out whether rTMS can restore that communication and whether doing so leads to measurable improvements in depression.
Interventions
- DEVICE Sham Stimulation
- DEVICE MagVenture MagPro TMS system
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2026-07 |
| Est. Completion | 2031-12 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07680153
The ClinicalTrials.gov registry entry for NCT07680153 describes a study currently listed as not yet recruiting, categorized as Phase 4. The registered enrollment target is 62 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Weill Medical College of Cornell University, which has 701 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Sham Stimulation is the first listed.
NCT07680153 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07680153 about?
NCT07680153 is a clinical study titled "Neuromodulation of Mood Switch Circuitry in Bipolar Disorder". This study is exploring a new approach to treating depression in people with bipolar disorder (BD). Investigators are testing whether a non-invasive form of brain stimulation can help us understand depressed-to-euthymic mood shifts and their related brain circuits in BD. Investigators in this study...
What is the current status of trial NCT07680153?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 62 participants. The study started on 2026-07. Estimated completion is 2031-12.
What interventions are being tested in trial NCT07680153?
The interventions under investigation include: Sham Stimulation (DEVICE), MagVenture MagPro TMS system (DEVICE).
Who is sponsoring clinical trial NCT07680153?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
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