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NCT07659795 · ClinicalTrials.gov registry record · Phase 2
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer
A Phase 2 study, sponsored by Verastem.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 150
- Enrollment target
NCT07659795: Recruiting Phase 2 study, sponsored by Verastem.
NCT07659795 is a Phase 2 study that is actively recruiting participants, run by Verastem. The registered enrollment target is 150 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (13% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07659795, a Phase 2 study, is actively recruiting participants, sponsored by Verastem.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 150 participants
- Enrollment target
Study Summary
This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab or panitumumab and cetuximab plus mFOLFOX in patients with metastatic KRAS G12D - mutated Colorectal Cancer
Primary Outcome
Overall Response Rate per RECIST version 1.1, per blinded independent central review (BICR)
Interventions
- DRUG cetuximab
- DRUG panitumumab
- DRUG VS-7375
- DRUG Cetuximab + mFOLFOX6
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2026-07 |
| Est. Completion | 2028-12 |
| Phase | Phase 2 |
What NCT07659795 shows while recruiting
NCT07659795 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (13% higher).
The record links to 0 conditions, and to 4 interventions - of which cetuximab is the first listed.
NCT07659795 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07659795 about?
NCT07659795 is a clinical study titled "A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer". This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab or panitumumab and cetuximab plus mFOLFOX in patients with metastatic KRAS G12D - mutated Colorectal Cancer
What is the current status of trial NCT07659795?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2026-07. Estimated completion is 2028-12.
What interventions are being tested in trial NCT07659795?
The interventions under investigation include: cetuximab (DRUG), panitumumab (DRUG), VS-7375 (DRUG), Cetuximab + mFOLFOX6 (DRUG).
Who is sponsoring clinical trial NCT07659795?
This trial is sponsored by Verastem, which has 21 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07659795's enrollment target sits among peer trials
150 455th of 2000 higher than 1,510 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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