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NCT07653815 · ClinicalTrials.gov registry record · NA
Essential Oil-Based Product System for Digestive Support
A NA study, sponsored by dōTERRA International.
- Not yet
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT07653815: Clinical Trial NA study, sponsored by dōTERRA International.
NCT07653815 is a NA study that has not yet begun recruiting, run by dōTERRA International. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07653815, a NA study, has not yet begun recruiting, sponsored by dōTERRA International.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
This study aims to evaluate the efficacy of specific essential oils. Efficacy will be evaluated through changes, if any, to hsCRP, gene expression, and standard hematologic and metabolic parameters, as well as subjective health changes as measured by Gastrointestinal Symptom Rating Scale (GSRS), PROMIS Global Health survey, PROMIS Fatigue Scale, Immune Fitness Item Scale (IFIS), and the Immune Status Questionnaire (ISQ) in healthy volunteers. The main questions it aims to answer are: 1. Do specific essential oils affect gene expression and hematologic and metabolic parameters as measured in blood? 2. How do essential oils affect gut microbiome? 3. How does daily use of specific essential oils affect subjective quality of life and health parameters? 4. Is ingesting and topically applying specific essential oils daily safe, as measured by laboratory tests and adverse events? Two study products will be used: oil for topical use, supplement for internal use. The two products will be used together and compared to a placebo group. The topical oil contains a blend of ginger essential oil, peppermint essential oil, caraway essential oil, coriander essential oil, and anise essential oil. The supplement contains everything the oil has, plus anise essential oil. Participants will: * Be assigned one of the two groups. * Use the oil topically once each day for 4 weeks. * Take one supplement in the morning and one in the evening every day for 4 weeks. * Attend 2 study visits in which they provide blood and urine (females only) samples. * Complete 2 stool collection/microbiome kits * Complete surveys and subjective health assessments
Primary Outcome
Looking for within- and between treatment changes to Gastrointestinal Symptom Rating Scale (GSRS) from baseline to completion. The GSRS uses a 7-point Likert scale for the 15 questions regarding gastrointestinal symptoms with answers ranging from "No discomfort at all" to "Very severe discomfort." Scores range from 15 to 105, and the total score is the sum of all item scores. Higher scores indicate more severe GI symptoms.
Interventions
- DIETARY_SUPPLEMENT Placebo supplement
- OTHER Essential Oil
- DIETARY_SUPPLEMENT essential oil supplement
- OTHER placebo essential oil
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-11 |
| Est. Completion | 2026-12 |
| Phase | NA |
What is known before NCT07653815 opens enrollment
NCT07653815 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 4 interventions - of which Placebo supplement is the first listed.
NCT07653815 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07653815 about?
NCT07653815 is a clinical study titled "Essential Oil-Based Product System for Digestive Support". This study aims to evaluate the efficacy of specific essential oils. Efficacy will be evaluated through changes, if any, to hsCRP, gene expression, and standard hematologic and metabolic parameters, as well as subjective health changes as measured by Gastrointestinal Symptom Rating Scale (GSRS), PRO...
What is the current status of trial NCT07653815?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2026-11. Estimated completion is 2026-12.
What interventions are being tested in trial NCT07653815?
The interventions under investigation include: Placebo supplement (DIETARY_SUPPLEMENT), Essential Oil (OTHER), essential oil supplement (DIETARY_SUPPLEMENT), placebo essential oil (OTHER).
Who is sponsoring clinical trial NCT07653815?
This trial is sponsored by dōTERRA International, which has 8 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07653815's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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