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NCT07640061 · ClinicalTrials.gov registry record · Phase 1
Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release
A Phase 1 study, sponsored by Wright State University.
- Not yet
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT07640061: Clinical Trial Phase 1 study, sponsored by Wright State University.
NCT07640061 is a Phase 1 study that has not yet begun recruiting, run by Wright State University. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07640061, a Phase 1 study, has not yet begun recruiting, sponsored by Wright State University.
- NOT YET RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). The hypothesis to be tested in this study is that treatment with a single dose of 75mg of amitriptyline will block the MVP released from the skin from a very small localized burn injury.
Primary Outcome
To see the change from baseline in microvesicle particle release in the skin after a localized thermal burn injury. In this double-blinded placebo-controlled crossover study. Subjects are treated with placebo or 75mg amitriptyline and 90 minutes later a small area of anesthetized volar forearm skin will be treated with a heated 3.5 mm metal rod to generate a thermal burn injury. Skin biopsies of burned and nearby untreated area will be obtained 2 hours after localized burn injury. MVP will be me
Interventions
- DRUG Placebo
- DRUG Amitriptyline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2027-06 |
| Est. Completion | 2033-06 |
| Phase | Phase 1 |
What is known before NCT07640061 opens enrollment
NCT07640061 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT07640061 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07640061 about?
NCT07640061 is a clinical study titled "Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release". The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). The hypothesis to be tested in this study is that treatment with a single dose of 75mg of amitriptyline will block the MVP released from the skin from a very small localized bu...
What is the current status of trial NCT07640061?
This trial is currently not yet recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2027-06. Estimated completion is 2033-06.
What interventions are being tested in trial NCT07640061?
The interventions under investigation include: Placebo (DRUG), Amitriptyline (DRUG).
Who is sponsoring clinical trial NCT07640061?
This trial is sponsored by Wright State University, which has 32 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07640061's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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