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NCT07605858 · ClinicalTrials.gov registry record
Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep
A clinical trial, sponsored by Hospices Civils de Lyon.
- Recruiting
- Registry status
- 20
- Enrollment target
NCT07605858 is a clinical trial that is actively recruiting participants, run by Hospices Civils de Lyon. The registered enrollment target is 20 participants.
The verdict
NCT07605858 is actively recruiting participants, sponsored by Hospices Civils de Lyon.
- RECRUITING
- Registry status
- 20 participants
- Enrollment target
Study Summary
Interactions between epilepsy and sleep are numerous and bidirectional. Sleep can facilitate epileptic activity and seizures in several syndromes, while sleep deprivation increases cortical excitability and seizure susceptibility. Conversely, sleep disturbances are highly prevalent in patients with epilepsy (PWE). Using simultaneous stereoelectroencephalography (SEEG)-polysomnography, the investigators previously showed that sleep fragmentation in focal drug-resistant epilepsy is associated with both ictal and interictal epileptic activity, with increased interictal epileptiform discharges (IED) immediately before and during arousals. However, causality remains unclear, as sleep instability itself may promote epileptic discharges. Determining whether nocturnal seizures and IED directly induce awakenings is clinically important. Nocturnal epileptic activity is often considered less disabling than daytime seizures and rarely guides treatment decisions, yet demonstrating a direct impact on sleep continuity could support therapeutic strategies specifically targeting nocturnal epileptic activity to improve sleep quality. Beyond sleep continuity, epilepsy may also influence cognitive processes during sleep, including subjective sleep depth and dreaming. While the cognitive consequences of epilepsy during wakefulness are well established, relationships between epileptic activity, sleep architecture and subjective sleep experiences remain poorly understood. In a survey of 300 PWE, the investigators observed altered dream recall frequency and dream content, with seizure-related dreams associated with nocturnal seizures. However, retrospective morning reports cannot establish temporal relationships between epileptic discharges and dream phenomena, nor determine the influence of discharge localization or sleep stage. SEEG combined with direct electrical stimulation (DES) provides a unique framework to address these questions. DES is routinely used during presurgical evaluat
Interventions
- OTHER Direct Electric Stimulation (DES)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-06 |
| Est. Completion | 2028-06 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07605858
The ClinicalTrials.gov registry entry for NCT07605858 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hospices Civils de Lyon, which has 2 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Direct Electric Stimulation (DES) is the first listed.
NCT07605858 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07605858 about?
NCT07605858 is a clinical study titled "Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep". Interactions between epilepsy and sleep are numerous and bidirectional. Sleep can facilitate epileptic activity and seizures in several syndromes, while sleep deprivation increases cortical excitability and seizure susceptibility. Conversely, sleep disturbances are highly prevalent in patients with ...
What is the current status of trial NCT07605858?
This trial is currently recruiting. The enrollment target is 20 participants. The study started on 2026-06. Estimated completion is 2028-06.
What interventions are being tested in trial NCT07605858?
The interventions under investigation include: Direct Electric Stimulation (DES) (OTHER).
Who is sponsoring clinical trial NCT07605858?
This trial is sponsored by Hospices Civils de Lyon, which has 2 total clinical trials registered on ClinicalTrials.gov.
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