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NCT07599865 · ClinicalTrials.gov registry record · Phase 2
Periprosthetic Joint Infection Bubble Study
A Phase 2 study, sponsored by Thomas Jefferson University.
- Not yet
- Registry status
- Phase 2
- Development phase
- 100
- Enrollment target
NCT07599865 is a Phase 2 study that has not yet begun recruiting, run by Thomas Jefferson University. The registered enrollment target is 100 participants.
The verdict
NCT07599865, a Phase 2 study, has not yet begun recruiting, sponsored by Thomas Jefferson University.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 100 participants
- Enrollment target
Study Summary
Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control groups). Subjects in the active group will receive a local bolus injection of antibiotics and ultrasound-active microbubbles within 24 hours of their revision surgery. The fundamental hypothesis is that a decrease in re-infection rates of at least 24% can be achieved in the active group relative to controls.
Interventions
- DRUG Ultrasound-triggered microbubble destruction with antibiotics
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2026-06 |
| Est. Completion | 2030-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07599865
The ClinicalTrials.gov registry entry for NCT07599865 describes a study currently listed as not yet recruiting, categorized as Phase 2. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Thomas Jefferson University, which has 292 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Ultrasound-triggered microbubble destruction with antibiotics is the first listed.
NCT07599865 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07599865 about?
NCT07599865 is a clinical study titled "Periprosthetic Joint Infection Bubble Study". Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control groups). Subjects in the active group will receive a local bolus injectio...
What is the current status of trial NCT07599865?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2026-06. Estimated completion is 2030-06.
What interventions are being tested in trial NCT07599865?
The interventions under investigation include: Ultrasound-triggered microbubble destruction with antibiotics (DRUG).
Who is sponsoring clinical trial NCT07599865?
This trial is sponsored by Thomas Jefferson University, which has 292 total clinical trials registered on ClinicalTrials.gov.
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