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NCT07599865 · ClinicalTrials.gov registry record · Phase 2
Periprosthetic Joint Infection Bubble Study
A Phase 2 study, sponsored by Thomas Jefferson University.
- Not yet
- Registry status
- Phase 2
- Development phase
- 100
- Enrollment target
NCT07599865: Clinical Trial Phase 2 study, sponsored by Thomas Jefferson University.
NCT07599865 is a Phase 2 study that has not yet begun recruiting, run by Thomas Jefferson University. The registered enrollment target is 100 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (25% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07599865, a Phase 2 study, has not yet begun recruiting, sponsored by Thomas Jefferson University.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 100 participants
- Enrollment target
Study Summary
Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control groups). Subjects in the active group will receive a local bolus injection of antibiotics and ultrasound-active microbubbles within 24 hours of their revision surgery. The fundamental hypothesis is that a decrease in re-infection rates of at least 24% can be achieved in the active group relative to controls.
Primary Outcome
Rate of re-infection within 2 years post-intervention
Interventions
- DRUG Ultrasound-triggered microbubble destruction with antibiotics
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2026-06 |
| Est. Completion | 2030-06 |
| Phase | Phase 2 |
What is known before NCT07599865 opens enrollment
NCT07599865 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (25% lower).
The record links to 0 conditions, and to 1 intervention - of which Ultrasound-triggered microbubble destruction with antibiotics is the first listed.
NCT07599865 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07599865 about?
NCT07599865 is a clinical study titled "Periprosthetic Joint Infection Bubble Study". Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control groups). Subjects in the active group will receive a local bolus injectio...
What is the current status of trial NCT07599865?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2026-06. Estimated completion is 2030-06.
What interventions are being tested in trial NCT07599865?
The interventions under investigation include: Ultrasound-triggered microbubble destruction with antibiotics (DRUG).
Who is sponsoring clinical trial NCT07599865?
This trial is sponsored by Thomas Jefferson University, which has 292 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07599865's enrollment target sits among peer trials
100 672nd of 2000 higher than 1,263 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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