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NCT07558265 · ClinicalTrials.gov registry record · NA
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
A NA study, sponsored by Ohio State University.
- Not yet
- Registry status
- NA
- Development phase
- 500
- Enrollment target
NCT07558265: Clinical Trial NA study, sponsored by Ohio State University.
NCT07558265 is a NA study that has not yet begun recruiting, run by Ohio State University. The registered enrollment target is 500 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (64% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07558265, a NA study, has not yet begun recruiting, sponsored by Ohio State University.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 500 participants
- Enrollment target
Study Summary
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in which blood oxygen levels are dangerously low and require urgent treatment. This study compares two commonly used non-invasive respiratory support strategies to evaluate their effectiveness and safety, based on important patient outcomes during hospitalization, including survival, the need for invasive mechanical ventilation, and the duration of respiratory support. Participants will be randomly assigned (with an equal chance) to receive one of the following treatments: * Non-Invasive Positive Pressure Ventilation (NIPPV): Oxygen delivered under pressure through a face mask. * High-Flow Nasal Oxygen (HFNO): Oxygen delivered at high-flow through a specially designed nasal cannula placed in the nostrils. Researchers will compare the two treatment strategies using a hierarchical assessment of major pulmonary outcomes, including: * Hospital survival * Days on mechanical ventilation * Duration of non-invasive respiratory support As part of the study, researchers will collect: * Blood and urine samples * Physiologic measurements (such as chest movement measured through sensors placed on the skin) * Information from participants' medical records
Primary Outcome
Composite of: 1. Hospital Death 2. Ventilator Days 3. Non-Invasive Respiratory Support (NIRS) Hours
Interventions
- DEVICE Non-Invasive Positive Pressure Ventilation
- DEVICE High Flow Nasal Oxygen
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2026-07 |
| Est. Completion | 2031-08 |
| Phase | NA |
What is known before NCT07558265 opens enrollment
NCT07558265 is an interventional study that assigns participants to a tested intervention. The registered 500 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (64% lower).
The record links to 0 conditions, and to 2 interventions - of which Non-Invasive Positive Pressure Ventilation is the first listed.
NCT07558265 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07558265 about?
NCT07558265 is a clinical study titled "WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department". The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in which blood oxygen levels are dangerously low and require urgent treatment....
What is the current status of trial NCT07558265?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 500 participants. The study started on 2026-07. Estimated completion is 2031-08.
What interventions are being tested in trial NCT07558265?
The interventions under investigation include: Non-Invasive Positive Pressure Ventilation (DEVICE), High Flow Nasal Oxygen (DEVICE).
Who is sponsoring clinical trial NCT07558265?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07558265's enrollment target sits among peer trials
500 193rd of 2000 higher than 1,788 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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