Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07537764 · ClinicalTrials.gov registry record · Early Phase 1
Predictors & Mechanisms of Adolescent PTSD
A Early Phase 1 study, sponsored by Medical University of South Carolina.
- Not yet
- Registry status
- Early Phase 1
- Development phase
- 180
- Enrollment target
NCT07537764: Clinical Trial Early Phase 1 study, sponsored by Medical University of South Carolina.
NCT07537764 is a Early Phase 1 study that has not yet begun recruiting, run by Medical University of South Carolina. The registered enrollment target is 180 participants, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (240% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07537764, a Early Phase 1 study, has not yet begun recruiting, sponsored by Medical University of South Carolina.
- NOT YET RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 180 participants
- Enrollment target
Study Summary
This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to potential threats, regulating emotions, and repeatedly imagining details of a personally experienced stressful or traumatic event using a script-driven imagery task. The study evaluates whether repeated imaginal exposure is associated with changes in anxiety and physiological responses across sessions, and whether baseline patterns of threat reactivity and emotion regulation are associated with individual differences in response to the exposure task. Outcomes include self-reported anxiety, subjective distress ratings, and psychophysiological indices such as heart rate, skin conductance, and electromyographic activity. The goal of this research is to improve understanding of biobehavioral processes related to trauma exposure in adolescents and to identify potential predictors of response to exposure-based intervention components relevant to posttraumatic stress disorder (PTSD).
Interventions
- BEHAVIORAL Repeated imaginal exposure: Script Driven Imagery (SDI) task
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2026-09 |
| Est. Completion | 2031-03 |
| Phase | Early Phase 1 |
What is known before NCT07537764 opens enrollment
NCT07537764 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (240% higher).
The record links to 0 conditions, and to 1 intervention - of which Repeated imaginal exposure: Script Driven Imagery (SDI) task is the first listed.
NCT07537764 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07537764 about?
NCT07537764 is a clinical study titled "Predictors & Mechanisms of Adolescent PTSD". This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to potential threats, regulating emotions, and repeatedly imagining detai...
What is the current status of trial NCT07537764?
This trial is currently not yet recruiting. It is a Early Phase 1 study. The enrollment target is 180 participants. The study started on 2026-09. Estimated completion is 2031-03.
What interventions are being tested in trial NCT07537764?
The interventions under investigation include: Repeated imaginal exposure: Script Driven Imagery (SDI) task (BEHAVIORAL).
Who is sponsoring clinical trial NCT07537764?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07537764's enrollment target sits among peer trials
180 75th of 2000 higher than 1,924 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01558804 · 180 participants
GRoup A StrePtococcus
- NCT02932176 · 180 participants
Machine Learning for Handheld Vascular Studies
- NCT03384563 · 180 participants · Phase 4
Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane
- NCT03423628 · 180 participants · Phase 1
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia