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NCT07511179 · ClinicalTrials.gov registry record · NA
Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia
A NA study, sponsored by Johns Hopkins University.
- Not yet
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT07511179: Clinical Trial NA study, sponsored by Johns Hopkins University.
NCT07511179 is a NA study that has not yet begun recruiting, run by Johns Hopkins University. The registered enrollment target is 10 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07511179, a NA study, has not yet begun recruiting, sponsored by Johns Hopkins University.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with Primary Progressive Aphasia (PPA), addressing the inconsistent results of generic brain stimulation protocols. By integrating artificial intelligence (AI)-derived insights with real-time data, the study aims to customize transcranial electrical stimulation (tES) parameters, including electrode placement, intensity, and frequency to target the specific brain regions responsible for abnormal signaling in each participant. Over the intervention period paired with computerized cognitive training, the project will evaluate improvements in learning, memory, and functional connectivity, while simultaneously identifying clinical and physiological predictors to determine the viability of transitioning this low-cost, non-invasive technology into a remotely supervised, home-based therapy setting. The study duration will be a total of 6-8 weeks.
Primary Outcome
Each trained word-list (practiced during the intervention period) will consist of 12 semantically related words (e.g., birds). Word lists will be constructed using psycholinguistic databases. There will be 5 Trials to learn each list. The investigators will compute the raw score of items correctly recalled by summing all scores from Trial 1 to Trial 5 and transforming to percent correct (range: 0-100%) at each time point of the study. Increase in scores is considered a benefit.
Interventions
- DEVICE Active tES
- BEHAVIORAL Cognitive Interventions
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2026-06 |
| Est. Completion | 2026-08 |
| Phase | NA |
What is known before NCT07511179 opens enrollment
NCT07511179 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Active tES is the first listed.
NCT07511179 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07511179 about?
NCT07511179 is a clinical study titled "Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia". This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with Primary Progressive Aphasia (PPA), addressing the inconsistent results of generic brain stimulation protoc...
What is the current status of trial NCT07511179?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2026-06. Estimated completion is 2026-08.
What interventions are being tested in trial NCT07511179?
The interventions under investigation include: Active tES (DEVICE), Cognitive Interventions (BEHAVIORAL).
Who is sponsoring clinical trial NCT07511179?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07511179's enrollment target sits among peer trials
10 1927th of 2000 higher than 26 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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