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NCT07469150 · ClinicalTrials.gov registry record · NA
Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment
A NA study, sponsored by University of Alabama at Birmingham.
- Not yet
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT07469150 is a NA study that has not yet begun recruiting, run by University of Alabama at Birmingham. The registered enrollment target is 60 participants.
The verdict
NCT07469150, a NA study, has not yet begun recruiting, sponsored by University of Alabama at Birmingham.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
Post-treatment apical periodontitis is commonly associated with persistent intracanal infection following root canal treatment. Effective disinfection of the complex root canal system during nonsurgical retreatment remains challenging due to anatomical complexities that may harbor microbial biofilms. Conventional retreatment protocols typically involve nickel-titanium rotary instrumentation combined with irrigation using sodium hypochlorite and activation techniques such as Passive Ultrasonic Irrigation (PUI). The GentleWave System (GWS) is a minimally invasive irrigation technology designed to enhance tissue dissolution and microbial removal through multisonic energy, advanced fluid dynamics, and negative pressure. Although preliminary studies suggest promising results in root canal disinfection and patient outcomes, high-level clinical evidence comparing GWS with conventional retreatment techniques remains limited, particularly in molar teeth with post-treatment apical periodontitis. This randomized clinical study aims to compare the disinfection efficacy of GWS with a conventional nickel-titanium rotary instrumentation protocol combined with PUI in nonsurgical retreatment of molars with post-treatment apical periodontitis. Intracanal bacterial load will be quantified using quantitative polymerase chain reaction (qPCR), and microbial composition will be analyzed using next-generation sequencing (NGS). Residual organic debris will be evaluated using the chairside diagnostic device Endocator and facultative bacterial culturing. Postoperative pain levels will also be recorded to assess short-term clinical outcomes. The results of this study will provide clinical evidence regarding the comparative effectiveness, safety, and potential advantages of advanced irrigation technology for root canal disinfection in complex retreatment cases.
Interventions
- PROCEDURE GentleWave System
- PROCEDURE Conventional rotary instrumentation with passive ultrasonic irrigation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2027-07 |
| Est. Completion | 2030-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07469150
The ClinicalTrials.gov registry entry for NCT07469150 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Alabama at Birmingham, which has 1,160 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which GentleWave System is the first listed.
NCT07469150 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07469150 about?
NCT07469150 is a clinical study titled "Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment". Post-treatment apical periodontitis is commonly associated with persistent intracanal infection following root canal treatment. Effective disinfection of the complex root canal system during nonsurgical retreatment remains challenging due to anatomical complexities that may harbor microbial biofilms...
What is the current status of trial NCT07469150?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2027-07. Estimated completion is 2030-12.
What interventions are being tested in trial NCT07469150?
The interventions under investigation include: GentleWave System (PROCEDURE), Conventional rotary instrumentation with passive ultrasonic irrigation (PROCEDURE).
Who is sponsoring clinical trial NCT07469150?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
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