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NCT07428746 · ClinicalTrials.gov registry record · Phase 3
Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes
A Phase 3 study, sponsored by Emory University.
- Not yet
- Registry status
- Phase 3
- Development phase
- 20
- Enrollment target
NCT07428746: Clinical Trial Phase 3 study, sponsored by Emory University.
NCT07428746 is a Phase 3 study that has not yet begun recruiting, run by Emory University. The registered enrollment target is 20 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07428746, a Phase 3 study, has not yet begun recruiting, sponsored by Emory University.
- NOT YET RECRUITING
- Registry status
- Phase 3
- Development phase
- 20 participants
- Enrollment target
Study Summary
The goal of this study is to learn how GLP-1 receptor agonist therapy affects muscle and bone health in older females over age 65 with type 2 diabetes. The main question it aims to answer is whether or not 6 months of GLP-1 RA therapy affects muscle strength. Participants will: * Receive GLP-1 RA therapy as part of their routine clinical care * Complete muscle strength assessments (hand grip strength, Timed Up and Go test) * Provide blood samples for bone turnover markers * Undergo bone mineral density testing
Primary Outcome
Handgrip strength is a validated indicator of overall muscle strength and a core diagnostic component of sarcopenia. HGS will be assessed using a calibrated hydraulic hand dynamometer. Output is recorded in kilograms (kg) of force. Higher values indicate greater muscle strength
Interventions
- DRUG Semaglutide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-04 |
| Est. Completion | 2028-11 |
| Phase | Phase 3 |
What is known before NCT07428746 opens enrollment
NCT07428746 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which Semaglutide is the first listed.
NCT07428746 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07428746 about?
NCT07428746 is a clinical study titled "Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes". The goal of this study is to learn how GLP-1 receptor agonist therapy affects muscle and bone health in older females over age 65 with type 2 diabetes. The main question it aims to answer is whether or not 6 months of GLP-1 RA therapy affects muscle strength. Participants will: * Receive GLP-1 RA...
What is the current status of trial NCT07428746?
This trial is currently not yet recruiting. It is a Phase 3 study. The enrollment target is 20 participants. The study started on 2026-04. Estimated completion is 2028-11.
What interventions are being tested in trial NCT07428746?
The interventions under investigation include: Semaglutide (DRUG).
Who is sponsoring clinical trial NCT07428746?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07428746's enrollment target sits among peer trials
20 1956th of 2000 higher than 32 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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