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NCT07417137 · ClinicalTrials.gov registry record
A Natural History Study of Angelman Syndrome
A clinical trial, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- 40
- Enrollment target
NCT07417137: Recruiting study, sponsored by Massachusetts General Hospital.
NCT07417137 is a clinical trial that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 40 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07417137 is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- 40 participants
- Enrollment target
Study Summary
The goal of this observational study is to learn about the natural progression of Angelman syndrome (AS) in children and adults with a confirmed genetic diagnosis of AS. The main questions it aims to answer are: * How do developmental skills, such as communication, motor abilities, and adaptive behaviors, change over a 1-year period in people with AS? * Are there specific patterns in brain activity or sleep that are associated with changes in AS symptoms over time? Participants will: * Visit the study site 5 times over 1 year (approximately every 3 months) for assessments. * Complete tests and questionnaires about development, behaviors, and sleep with the help of their caregivers. * Undergo electroencephalograms (EEGs) to measure brain activity and wear a sleep-monitoring device at home (to collect actigraphy data).
Primary Outcome
The Bayley-4 Cognitive subscale assesses cognitive development in children. Growth score equivalents are derived from developmental growth scale values (GSVs) that provide an equal-interval scale for measuring developmental change over time. Higher scores indicate greater cognitive development.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-06 |
| Est. Completion | 2029-09 |
What NCT07417137 shows while recruiting
NCT07417137 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT07417137 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07417137 about?
NCT07417137 is a clinical study titled "A Natural History Study of Angelman Syndrome". The goal of this observational study is to learn about the natural progression of Angelman syndrome (AS) in children and adults with a confirmed genetic diagnosis of AS. The main questions it aims to answer are: * How do developmental skills, such as communication, motor abilities, and adaptive beh...
What is the current status of trial NCT07417137?
This trial is currently recruiting. The enrollment target is 40 participants. The study started on 2026-06. Estimated completion is 2029-09.
Who is sponsoring clinical trial NCT07417137?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
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