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Evaluation of the Safety and Efficacy of GLK-321 in Subjects With Demodex Blepharitis
NCT07400965 · View on ClinicalTrials.gov ↗
Study Summary
This is a randomized, double-masked, placebo-controlled, dose-ranging, parallel-group, multi-center study designed to evaluate the safety and efficacy of GLK-321 in patients with Demodex blepharitis.
Conditions Studied
Interventions
- DRUG GLK-321 low dose BID
- DRUG GLK-321 mid dose BID
- DRUG GLK-321 high dose BID
- DRUG GLK-321 high dose QD
- DRUG Placebo BID
Study Locations (1)
California
- Glaukos Clinical Study Site — Newport Beach
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2025-12-05 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07400965
The ClinicalTrials.gov registry entry for NCT07400965 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Glaukos Corporation, which has 45 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Demodex Blepharitis appearing as the primary indexed condition, and to 5 interventions — of which GLK-321 low dose BID is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07400965 reports 1 study location spanning 1 distinct geographic area — top geographies include California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07400965 about?
NCT07400965 is a clinical study titled "Evaluation of the Safety and Efficacy of GLK-321 in Subjects With Demodex Blepharitis". This is a randomized, double-masked, placebo-controlled, dose-ranging, parallel-group, multi-center study designed to evaluate the safety and efficacy of GLK-321 in patients with Demodex blepharitis.
What is the current status of trial NCT07400965?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 250 participants. The study started on 2025-12-05. Estimated completion is 2026-11.
What conditions does trial NCT07400965 study?
This clinical trial studies the following conditions: Demodex Blepharitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07400965?
The interventions under investigation include: GLK-321 low dose BID (DRUG), GLK-321 mid dose BID (DRUG), GLK-321 high dose BID (DRUG), GLK-321 high dose QD (DRUG), Placebo BID (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07400965?
This trial is sponsored by Glaukos Corporation, which has 45 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07400965 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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