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NCT07400146 · ClinicalTrials.gov registry record · Phase 4
Bupivacaine With Epinephrine Over Diaphragm in Laparoscopy
A Phase 4 study, sponsored by Cedars-Sinai Medical Center.
- Not yet
- Registry status
- Phase 4
- Development phase
- 100
- Enrollment target
NCT07400146: Clinical Trial Phase 4 study, sponsored by Cedars-Sinai Medical Center.
NCT07400146 is a Phase 4 study that has not yet begun recruiting, run by Cedars-Sinai Medical Center. The registered enrollment target is 100 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (81% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07400146, a Phase 4 study, has not yet begun recruiting, sponsored by Cedars-Sinai Medical Center.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 100 participants
- Enrollment target
Study Summary
Postoperative shoulder pain is often reported to be particularly bothersome after laparoscopy. The benefits of local anesthetic, such as bupivacaine, applied to subcutaneous tissue for general postoperative pain management after surgery is well established. However, there have been no studies on sprayed bupivacaine over the diaphragm to reduce shoulder pain in laparoscopic surgery. The purpose of the study is to evaluate if sprayed infra-diaphragmatic bupivacaine compared to placebo (saline) will improve postoperative shoulder pain in patients undergoing benign laparoscopic gynecologic surgery. The entire study will be conducted at Cedar Sinai Medical Center.
Primary Outcome
Reported right shoulder pain score using visual analog score (VAS) 24 hours postoperatively Null hypothesis = pain scores will not differ among the bupivacaine with epinephrine vs no intervention group Alternative hypothesis = pain scores will be lower among the bupivacaine with epinephrine group Assessed using the validated 100-mm scale with a range of 0-10 (11-point numerical rating scale), an ordinal scale Analyzed using the Kruskall Wallis test (as the data from the scale is typically not n
Interventions
- DRUG Instillation of Bupivacaine with epinephrine over the diaphragm
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2026-02 |
| Est. Completion | 2026-08 |
| Phase | Phase 4 |
What is known before NCT07400146 opens enrollment
NCT07400146 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (81% lower).
The record links to 0 conditions, and to 1 intervention - of which Instillation of Bupivacaine with epinephrine over the diaphragm is the first listed.
NCT07400146 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07400146 about?
NCT07400146 is a clinical study titled "Bupivacaine With Epinephrine Over Diaphragm in Laparoscopy". Postoperative shoulder pain is often reported to be particularly bothersome after laparoscopy. The benefits of local anesthetic, such as bupivacaine, applied to subcutaneous tissue for general postoperative pain management after surgery is well established. However, there have been no studies on spr...
What is the current status of trial NCT07400146?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 100 participants. The study started on 2026-02. Estimated completion is 2026-08.
What interventions are being tested in trial NCT07400146?
The interventions under investigation include: Instillation of Bupivacaine with epinephrine over the diaphragm (DRUG).
Who is sponsoring clinical trial NCT07400146?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07400146's enrollment target sits among peer trials
100 770th of 2000 higher than 1,148 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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