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NCT07387796 · ClinicalTrials.gov registry record · NA
Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation
A NA study, sponsored by The University of Texas at Dallas.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT07387796 is a NA study that is actively recruiting participants, run by The University of Texas at Dallas. The registered enrollment target is 40 participants.
The verdict
NCT07387796, a NA study, is actively recruiting participants, sponsored by The University of Texas at Dallas.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
The goal of this clinical study with research procedures is to learn how stopping and restarting tirzepatide (a medication that helps regulate blood sugar and appetite) affects brain activity, behavior, and health in adults ages 18-70 who are currently taking tirzepatide. Specifically, the study aims to examine how a short pause in tirzepatide affects hunger, mood, sleep, and daily functioning; how stopping and restarting tirzepatide alters brain chemistry and brain responses to food-related images; and how these changes relate to health measures such as quality of life and emotional well-being. There is no comparison group; instead, researchers will assess changes within each participant across three time points: while taking tirzepatide, after stopping it for 3-4 weeks, and after restarting it for 6-8 weeks. Participants will attend three in-person visits lasting approximately 3-4 hours each, during which they will complete interviews, questionnaires, and cognitive tasks; provide a urine sample (pregnancy screening for females); undergo a brain scan using magnetic resonance imaging (MRI) and MR spectroscopy (MRS); and receive a kit to provide a small stool sample. Participants will also complete two brief check-in phone calls between visits and the online BrainHealth Index between sessions, which includes surveys and cognitive tasks. All changes to tirzepatide use will occur under the supervision of a study physician to support participant safety and comfort, and the total study duration is approximately 13 weeks.
Interventions
- OTHER Discontinuation and Reinitiation of Tirzepatide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-06 |
| Est. Completion | 2029-02 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07387796
The ClinicalTrials.gov registry entry for NCT07387796 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is The University of Texas at Dallas, which has 50 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Discontinuation and Reinitiation of Tirzepatide is the first listed.
NCT07387796 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07387796 about?
NCT07387796 is a clinical study titled "Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation". The goal of this clinical study with research procedures is to learn how stopping and restarting tirzepatide (a medication that helps regulate blood sugar and appetite) affects brain activity, behavior, and health in adults ages 18-70 who are currently taking tirzepatide. Specifically, the study aim...
What is the current status of trial NCT07387796?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2026-06. Estimated completion is 2029-02.
What interventions are being tested in trial NCT07387796?
The interventions under investigation include: Discontinuation and Reinitiation of Tirzepatide (OTHER).
Who is sponsoring clinical trial NCT07387796?
This trial is sponsored by The University of Texas at Dallas, which has 50 total clinical trials registered on ClinicalTrials.gov.
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