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NCT07288437 · ClinicalTrials.gov registry record · NA
Deep Brain Stimulation for Spinocerebellar Ataxia
A NA study of Spinocerebellar Ataxia Type 6 and Spinocerebellar Ataxia (SCA), sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- NA
- Development phase
- 5
- Enrollment target
- 2
- Study locations
NCT07288437: Recruiting NA study of Spinocerebellar Ataxia Type 6 and Spinocerebellar Ataxia (SCA), sponsored by University of California, San Francisco.
NCT07288437 is a NA study of Spinocerebellar Ataxia Type 6 and Spinocerebellar Ataxia (SCA) that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 5 participants, below the 114-participant average among 3 other Spinocerebellar Ataxia Type 6 trials with a reported enrollment target (96% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07288437, a NA study of Spinocerebellar Ataxia Type 6 and Spinocerebellar Ataxia (SCA), is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this clinical trial is to test the safety of placing Deep Brain Stimulators (DBS) in the cerebellum and using electrical stimulation of that part of the brain to treat symptoms related to the participants spinocerebellar ataxia. Five adults diagnosed with spinocerebellar ataxia type 6 (SCA6) with inadequate cerebellar symptom relief will be implanted with a Medtronic Percept Primary Cell Neurostimulator. The device will be implanted into the dentate nucleus, which is a structure located within the cerebellum that is responsible for controlling movement and balance. Specifically, the investigators will be using adaptive deep brain stimulation (aDBS), which analyzes brain signals and automatically adjusts the strength, timing, and pattern of stimulation according to the patient's needs at any given moment. This study will evaluate the feasibility, safety, and tolerability of aDBS in SCA6 patients.
Primary Outcome
SARA is a clinical scale that assesses a variety of different impairments for individuals with cerebellar ataxia. The scale includes 8 different items that are related to gait, stance, sitting, speech, finger-chase test, nose-finger test, fast alternating movements, and heel-shin test. The total amount of points on SARA ranges from 0 (no ataxia) to 40 (most severe ataxia). This study requires participants to have a minimum SARA score of at least 8 so that people who are relatively early in their
Conditions Studied
Interventions
- DEVICE Deep Brain Stimulation (DBS)
Study Locations (2)
California
- UCSF Weill Institute for Neurosciences - San Francisco
- University of California, San Francisco - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2026-03 |
| Est. Completion | 2031-03 |
| Phase | NA |
What NCT07288437 shows while recruiting
NCT07288437 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 114-participant average among 3 other Spinocerebellar Ataxia Type 6 trials with a reported enrollment target (96% lower).
The record links to 2 conditions, with Spinocerebellar Ataxia Type 6 appearing as the primary indexed condition, and to 1 intervention - of which Deep Brain Stimulation (DBS) is the first listed.
NCT07288437 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07288437 about?
NCT07288437 is a clinical study titled "Deep Brain Stimulation for Spinocerebellar Ataxia". The goal of this clinical trial is to test the safety of placing Deep Brain Stimulators (DBS) in the cerebellum and using electrical stimulation of that part of the brain to treat symptoms related to the participants spinocerebellar ataxia. Five adults diagnosed with spinocerebellar ataxia type 6 (S...
What is the current status of trial NCT07288437?
This trial is currently recruiting. It is a NA study. The enrollment target is 5 participants. The study started on 2026-03. Estimated completion is 2031-03.
What conditions does trial NCT07288437 study?
This clinical trial studies the following conditions: Spinocerebellar Ataxia Type 6, Spinocerebellar Ataxia (SCA).
What interventions are being tested in trial NCT07288437?
The interventions under investigation include: Deep Brain Stimulation (DBS) (DEVICE).
Who is sponsoring clinical trial NCT07288437?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07288437 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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