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RECRUITING Phase 2

A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)

NCT07288138 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this trial is to evaluate the dose-dependent and comparative effects of ECC4703 (low and high dose), ECC0509 (low and high dose), and their combination on hepatic fat reduction as assessed by change in magnetic resonance imaging proton density fat fraction (MRI-PDFF) at Week 12.

Interventions

  • DRUG Placebo
  • DRUG ECC4703
  • DRUG ECC0509

Study Locations (20)

Florida

  • Synergy Healthcare — Bradenton
  • Synergy Healthcare — Bradenton
  • Health Awareness, Inc. — Jupiter
  • Floridian Clinical Research, LLC — Miami Lakes
  • Ocala GI Research — Ocala
  • Progressive Medical Research — Port Orange
  • ClinCloud, LLC — Viera

Arizona

  • Arizona Liver Health — Chandler
  • Arizona Liver Health - Peoria — Peoria
  • Adobe Clinical Research, LLC — Tucson
  • Arizona Liver Health - Tucson — Tucson

Louisiana

  • Tandem Clinical Research — Covington
  • Tandem Clinical Research — Houma
  • Tandem Clinical Research GI, LLC — Marrero

Arkansas

  • Arkansas Gastroenterology, P.A — Little Rock
  • ARcare Center for Clinical Research — Little Rock

California

  • ARK Clinical Research - Fountain Valley — Fountain Valley
  • Ark Clinical Research — Long Beach

Georgia

  • Gastrointestinal Specialists of Georgia, PC — Marietta

Indiana

  • Digestive Research Alliance of Michiana — South Bend

Trial Details

FieldValue
Enrollment Target 160 participants
Start Date 2025-12-15
Est. Completion 2026-10-30
Phase Phase 2

Sponsor

Eccogene

29 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07288138

The ClinicalTrials.gov registry entry for NCT07288138 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eccogene, which has 29 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Metabolic Dysfunction-associated Steatohepatitis appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07288138 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Florida, Arizona, Louisiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07288138 about?

NCT07288138 is a clinical study titled "A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)". The primary objective of this trial is to evaluate the dose-dependent and comparative effects of ECC4703 (low and high dose), ECC0509 (low and high dose), and their combination on hepatic fat reduction as assessed by change in magnetic resonance imaging proton density fat fraction (MRI-PDFF) at Week...

What is the current status of trial NCT07288138?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 160 participants. The study started on 2025-12-15. Estimated completion is 2026-10-30.

What conditions does trial NCT07288138 study?

This clinical trial studies the following conditions: Metabolic Dysfunction-associated Steatohepatitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07288138?

The interventions under investigation include: Placebo (DRUG), ECC4703 (DRUG), ECC0509 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07288138?

This trial is sponsored by Eccogene, which has 29 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07288138 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial