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A Study to Evaluate Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)
NCT07204275 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).
Conditions Studied
Interventions
- DRUG Tacrolimus
- DRUG Povetacicept
Study Locations (20)
Texas
- El Paso Kidney Specialists — El Paso
- Provecta Research Network — Houston
- DaVita Clinical Research Houston — Houston
- Davita Clinical Research San Antonio — San Antonio
Florida
- Bioresearch Partner — Miami
- CTR Oakwater, LLC — Orlando
- Clinical Site Partners, LLC - Orlando — Winter Park
California
- Academic Medical Research Institute (AMRI) — Los Angeles
- Valiance Clinical Research - Internal Medicine — Tarzana
Georgia
- DaVita Clinical Research Columbus — Columbus
- Georgia Nephrology — Lawrenceville
South Carolina
- Carolina Nephrology Greenville — Greenville
- Carolina Nephrology, PA — Spartanburg
Alabama
- Renal Associates — Montgomery
Arizona
- Southwest Kidney Institute, PLC (SKI) - Surprise — Surprise
Colorado
- Western Nephrology & Metabolic Bone Disease PC — Arvada
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 176 participants |
| Start Date | 2025-09-30 |
| Est. Completion | 2028-12-29 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07204275
The ClinicalTrials.gov registry entry for NCT07204275 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 176 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vertex Pharmaceuticals Incorporated, which has 82 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Primary Membranous Nephropathy appearing as the primary indexed condition, and to 2 interventions — of which Tacrolimus is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07204275 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Texas, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07204275 about?
NCT07204275 is a clinical study titled "A Study to Evaluate Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)". The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).
What is the current status of trial NCT07204275?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 176 participants. The study started on 2025-09-30. Estimated completion is 2028-12-29.
What conditions does trial NCT07204275 study?
This clinical trial studies the following conditions: Primary Membranous Nephropathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07204275?
The interventions under investigation include: Tacrolimus (DRUG), Povetacicept (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07204275?
This trial is sponsored by Vertex Pharmaceuticals Incorporated, which has 82 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07204275 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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