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NCT07175571 · ClinicalTrials.gov registry record · NA
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
A NA study of Infertility, Female and Reproductive Techniques, Assisted, sponsored by Shady Grove Fertility Reproductive Science Center.
- Recruiting
- Registry status
- NA
- Development phase
- 95
- Enrollment target
- 1
- Study location
NCT07175571: Recruiting NA study of Infertility, Female and Reproductive Techniques, Assisted, sponsored by Shady Grove Fertility Reproductive Science Center.
NCT07175571 is a NA study of Infertility, Female and Reproductive Techniques, Assisted that is actively recruiting participants, run by Shady Grove Fertility Reproductive Science Center. The registered enrollment target is 95 participants, below the 378-participant average among 18 other Infertility, Female trials with a reported enrollment target (75% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07175571, a NA study of Infertility, Female and Reproductive Techniques, Assisted, is actively recruiting participants, sponsored by Shady Grove Fertility Reproductive Science Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 95 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when using frozen donor sperm in people who do not have male fertility problems. The main questions it aims to answer are: Does one method create more usable embryos (blastocysts) than the other? Is there a difference in how often fertilization does not happen at all? Do either of the methods lead to better embryo quality or early pregnancy? Participants will: Have their eggs divided into two groups. One group will be fertilized using ICSI (where a sperm is injected directly into an egg), and the other using conventional IVF (where eggs are mixed with sperm in a dish). The fertilization method for each egg will be randomly assigned, with a random process also used to determine the assignment of any extra egg when an odd number is collected. Continue regular fertility treatment while the study team compares the results of each fertilization method. This study includes people with non-male factor infertility and uses frozen donor sperm. It hopes to learn whether ICSI, which is often used even when it may not be needed, truly helps improve outcomes compared to conventional IVF in these cases.
Primary Outcome
The blastulation rate is defined as the number of "usable" blastocysts divided by the number of oocytes inseminated in each arm (ICSI and conventional IVF). A blastocyst is considered "usable" if it meets laboratory criteria for either cryopreservation or embryo transfer. Assessment is performed on Days 5-7 after fertilization using standard morphological grading under light microscopy.
Conditions Studied
Interventions
- PROCEDURE Intracytoplasmic Sperm Injection (ICSI)
- PROCEDURE Conventional Insemination (IVF)
Study Locations (1)
Maryland
- Shady Grove Fertility Rockville - Rockville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 95 participants |
| Start Date | 2025-09-15 |
| Est. Completion | 2026-05-01 |
| Phase | NA |
What NCT07175571 shows while recruiting
NCT07175571 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 95 participants, a relatively small participant target, below the 378-participant average among 18 other Infertility, Female trials with a reported enrollment target (75% lower).
The record links to 3 conditions, with Infertility, Female appearing as the primary indexed condition, and to 2 interventions - of which Intracytoplasmic Sperm Injection (ICSI) is the first listed.
NCT07175571 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT07175571 about?
NCT07175571 is a clinical study titled "SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques". The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when using frozen donor sperm in people who do not have male fertility prob...
What is the current status of trial NCT07175571?
This trial is currently recruiting. It is a NA study. The enrollment target is 95 participants. The study started on 2025-09-15. Estimated completion is 2026-05-01.
What conditions does trial NCT07175571 study?
This clinical trial studies the following conditions: Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro.
What interventions are being tested in trial NCT07175571?
The interventions under investigation include: Intracytoplasmic Sperm Injection (ICSI) (PROCEDURE), Conventional Insemination (IVF) (PROCEDURE).
Who is sponsoring clinical trial NCT07175571?
This trial is sponsored by Shady Grove Fertility Reproductive Science Center, which has 6 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07175571 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07175571's enrollment target sits among peer trials
95 10th of 18 higher than 9 of 18 other Infertility, Female trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Infertility, Female trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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