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NCT07164105 · ClinicalTrials.gov registry record · NA
LIFU Mechanisms for PTSD in Healthcare Workers
A NA study of PTSD and Trauma-related Symptoms, sponsored by Laureate Institute for Brain Research.
- Recruiting
- Registry status
- NA
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT07164105: Recruiting NA study of PTSD and Trauma-related Symptoms, sponsored by Laureate Institute for Brain Research.
NCT07164105 is a NA study of PTSD and Trauma-related Symptoms that is actively recruiting participants, run by Laureate Institute for Brain Research. The registered enrollment target is 66 participants, below the 194-participant average among 4 other PTSD and Trauma-related Symptoms trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07164105, a NA study of PTSD and Trauma-related Symptoms, is actively recruiting participants, sponsored by Laureate Institute for Brain Research.
- RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to evaluate whether low-intensity focused ultrasound (LIFU) of the ventral anterior cingulate cortex (vACC) can normalize dysfunctional brain activation patterns and behaviors in frontline healthcare workers with post-traumatic stress disorder. The main questions it aims to answer are: * Does LIFU of the vACC effect activity and connectivity of the vACC and amygdala? * Does LIFU of the vACC reduce post-traumatic stress symptoms? Researchers will compare LIFU to sham modulation to see if LIFU modulates activity of vACC-amygdala circuitry and affects threat sensitivity and emotion regulation. Participants will: * Complete two fMRI sessions (before and after LIFU) * Receive a single session of LIFU or sham modulation of the vACC * Wear a wearable device that tracks sleep and heart rate metrics
Primary Outcome
Percent BOLD signal change in vACC and amygdala regions of interest
Conditions Studied
Interventions
- DEVICE Low intensity focused ultrasound
- DEVICE Sham modulation
Study Locations (1)
Oklahoma
- Laureate Institute for Brain Research - Tulsa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2025-12-29 |
| Est. Completion | 2028-08 |
| Phase | NA |
What NCT07164105 shows while recruiting
NCT07164105 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 194-participant average among 4 other PTSD and Trauma-related Symptoms trials with a reported enrollment target (66% lower).
The record links to 1 condition, with PTSD and Trauma-related Symptoms appearing as the primary indexed condition, and to 2 interventions - of which Low intensity focused ultrasound is the first listed.
NCT07164105 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT07164105 about?
NCT07164105 is a clinical study titled "LIFU Mechanisms for PTSD in Healthcare Workers". The goal of this clinical trial is to evaluate whether low-intensity focused ultrasound (LIFU) of the ventral anterior cingulate cortex (vACC) can normalize dysfunctional brain activation patterns and behaviors in frontline healthcare workers with post-traumatic stress disorder. The main questions i...
What is the current status of trial NCT07164105?
This trial is currently recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2025-12-29. Estimated completion is 2028-08.
What conditions does trial NCT07164105 study?
This clinical trial studies the following conditions: PTSD and Trauma-related Symptoms.
What interventions are being tested in trial NCT07164105?
The interventions under investigation include: Low intensity focused ultrasound (DEVICE), Sham modulation (DEVICE).
Who is sponsoring clinical trial NCT07164105?
This trial is sponsored by Laureate Institute for Brain Research, which has 45 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07164105 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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