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NCT07161973 · ClinicalTrials.gov registry record · NA
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
A NA study of Mitochondrial Energetics and Dietary Nitrate, sponsored by Indiana University.
- Recruiting
- Registry status
- NA
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT07161973 is a NA study of Mitochondrial Energetics and Dietary Nitrate that is actively recruiting participants, run by Indiana University. The registered enrollment target is 24 participants. The trial reports 1 study location across 1 state.
The verdict
NCT07161973, a NA study of Mitochondrial Energetics and Dietary Nitrate, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition affecting untold millions of individuals each year. Such disuse leads to a rapid decline in muscle fiber area and hence whole muscle size, contributing to a decrease in strength, speed, and power as well as alterations in energy metabolism. Collectively, these changes lead to reduced physical function and contribute to the seriousness of any disease, illness (e.g., pneumonia), surgery (e.g., joint replacement), or injury (e.g., broken bone) accompanied by decreased muscular activity. Currently, there are no effective pharmacological treatments to prevent disuse-associated muscle wasting in humans. The above-described effects of disuse appear to be due, at least in part, to a decrease in nitric oxide (NO) bioavailability. Reduced synthesis of NO and/or increased NO destruction (due to increased production of oxygen free radicals) likely contributes to the mitochondrial changes, energetic abnormalities, and muscle atrophy resulting from immobilization. The objective of this study is to investigate the potential benefits of dietary nitrate supplementation on immobilization-induced changes in muscle contractile function and mitochondrial respiratory capacity in young healthy men. Our disuse-induced muscle atrophy model will involve wearing a knee brace for a period of 14 d.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Beetroot Juice - Active
- DIETARY_SUPPLEMENT Placebo Beetroot Juice Without Nitrate
Study Locations (1)
Indiana
- Indiana University Indianapolis - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2026-01-30 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07161973
The ClinicalTrials.gov registry entry for NCT07161973 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Indiana University, which has 890 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Mitochondrial Energetics appearing as the primary indexed condition, and to 2 interventions - of which Beetroot Juice - Active is the first listed.
NCT07161973 reports 1 study location spanning 1 distinct geographic area - top geographies include Indiana.
Frequently Asked Questions
What is clinical trial NCT07161973 about?
NCT07161973 is a clinical study titled "Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men". Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition affecting untold millions of individuals each year. Such disuse leads to a...
What is the current status of trial NCT07161973?
This trial is currently recruiting. It is a NA study. The enrollment target is 24 participants. The study started on 2026-01-30. Estimated completion is 2026-12-31.
What conditions does trial NCT07161973 study?
This clinical trial studies the following conditions: Mitochondrial Energetics, Dietary Nitrate, Disuse Atrophy (Muscle) of Lower Leg.
What interventions are being tested in trial NCT07161973?
The interventions under investigation include: Beetroot Juice - Active (DIETARY_SUPPLEMENT), Placebo Beetroot Juice Without Nitrate (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07161973?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07161973 being conducted?
This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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