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Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
NCT07155226 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to understand the safety, tolerability, efficacy, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of orally administered AZD3632 in participants with advanced haematologic malignancies with KMT2Ar, NPM1m, or other genotypes associated with homeobox (HOX) overexpression.
Conditions Studied
Interventions
- DRUG AZD3632
- DRUG Posaconazole
Study Locations (20)
Other
- Research Site — Fitzroy
- Research Site — Perth
- Research Site — Copenhagen
- Research Site — Dresden
- Research Site — Frankfurt A. Main
- Research Site — Halle
- Research Site — Heidelberg
- Research Site — München
- Research Site — Ulm
- Research Site — Bologna
- Research Site — Ravenna
- Research Site — Bunkyō City
- Research Site — Kashiwa
Illinois
- Research Site — Decatur
New York
- Research Site — New York
North Carolina
- Research Site — Durham
Oregon
- Research Site — Portland
Texas
- Research Site — Houston
Ontario
- Research Site — Toronto
Quebec
- Research Site — Montreal
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2026-01-09 |
| Est. Completion | 2029-02-15 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07155226
The ClinicalTrials.gov registry entry for NCT07155226 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 84 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Higher-risk Myelodysplastic Syndromes appearing as the primary indexed condition, and to 2 interventions — of which AZD3632 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07155226 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Illinois, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07155226 about?
NCT07155226 is a clinical study titled "Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression". The purpose of this study is to understand the safety, tolerability, efficacy, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of orally administered AZD3632 in participants with advanced haematologic malignancies with KMT2Ar, NPM1m, or other genotypes associated with homeobox (...
What is the current status of trial NCT07155226?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 84 participants. The study started on 2026-01-09. Estimated completion is 2029-02-15.
What conditions does trial NCT07155226 study?
This clinical trial studies the following conditions: Higher-risk Myelodysplastic Syndromes, Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07155226?
The interventions under investigation include: AZD3632 (DRUG), Posaconazole (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07155226?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07155226 being conducted?
This trial has 20 study locations across Illinois, New York, North Carolina, Oregon, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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