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NCT07134920 · ClinicalTrials.gov registry record
Norethindrone Impact on Receptiva Outcomes
A clinical trial of Infertility, Female and Infertility (IVF Patients), sponsored by Inception Fertility Research Institute.
- Active
- Registry status
- 700
- Enrollment target
- 1
- Study location
NCT07134920 is a study of Infertility, Female and Infertility (IVF Patients) that is active but no longer recruiting, run by Inception Fertility Research Institute. The registered enrollment target is 700 participants, above the 344-participant average among 18 other Infertility, Female trials with a reported enrollment target (103% higher). The trial reports 1 study location across 1 state.
The verdict
NCT07134920, a study of Infertility, Female and Infertility (IVF Patients), is active but no longer recruiting, sponsored by Inception Fertility Research Institute.
- ACTIVE NOT RECRUITING
- Registry status
- 700 participants
- Enrollment target
- 1
- Study location
Study Summary
This retrospective study aims to evaluate pregnancy outcomes in patients with a positive BCL6 test (ReceptivaDx, who were treated with either norethindrone acetate or Depo Lupron prior to embryo transfer. The current standard of care involves treatment with Depo Lupron, a GnRH agonist associated with significant hypoestrogenic side effects that mimic menopausal symptoms. Additionally, Depo Lupron is costly, with a retail price exceeding $2,000 per dose. In contrast, norethindrone acetate is a well-tolerated oral progestin, available at a fraction of the cost (under $100 for a one-month course). While prior studies have demonstrated comparable efficacy between Depo Lupron and norethindrone for managing endometriosis-associated pain, their relative effectiveness in improving reproductive outcomes-particularly in BCL6-positive patients undergoing embryo transfer-remains underexplored. This study seeks to address that gap by comparing ongoing pregnancy, live birth, and miscarriage rates between the two treatment groups. Hypothesis: IVF Patients testing positive for BCL6 and treated with norethindrone will not do worse than the current recommended treatment of 60 days Depo leuprolide as defined by two endpoint metrics, pregnancy rate and live birth rate.
Conditions Studied
Study Locations (1)
Pennsylvania
- Main Line Fertility - Bryn Mawr
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 700 participants |
| Start Date | 2025-08-12 |
| Est. Completion | 2026-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07134920
The ClinicalTrials.gov registry entry for NCT07134920 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 700 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 344-participant average among 18 other Infertility, Female trials with a reported enrollment target (103% higher). The listed sponsor is Inception Fertility Research Institute, which has 9 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Infertility, Female appearing as the primary indexed condition, and to 0 interventions.
NCT07134920 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT07134920 about?
NCT07134920 is a clinical study titled "Norethindrone Impact on Receptiva Outcomes". This retrospective study aims to evaluate pregnancy outcomes in patients with a positive BCL6 test (ReceptivaDx, who were treated with either norethindrone acetate or Depo Lupron prior to embryo transfer. The current standard of care involves treatment with Depo Lupron, a GnRH agonist associated wit...
What is the current status of trial NCT07134920?
This trial is currently active not recruiting. The enrollment target is 700 participants. The study started on 2025-08-12. Estimated completion is 2026-07.
What conditions does trial NCT07134920 study?
This clinical trial studies the following conditions: Infertility, Female, Infertility (IVF Patients).
Who is sponsoring clinical trial NCT07134920?
This trial is sponsored by Inception Fertility Research Institute, which has 9 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07134920 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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