Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07128602 · ClinicalTrials.gov registry record · Phase 1
Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction
A Phase 1 study of Anterior Cruciate Ligament Reconstruction Rehabilitation and Quadriceps Muscle Function, sponsored by Arcadia University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT07128602: Recruiting Phase 1 study of Anterior Cruciate Ligament Reconstruction Rehabilitation and Quadriceps Muscle Function, sponsored by Arcadia University.
NCT07128602 is a Phase 1 study of Anterior Cruciate Ligament Reconstruction Rehabilitation and Quadriceps Muscle Function that is actively recruiting participants, run by Arcadia University. The registered enrollment target is 42 participants, above the 37-participant average among 4 other Anterior Cruciate Ligament Reconstruction Rehabilitation trials with a reported enrollment target (14% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07128602, a Phase 1 study of Anterior Cruciate Ligament Reconstruction Rehabilitation and Quadriceps Muscle Function, is actively recruiting participants, sponsored by Arcadia University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, the investigators measure thigh muscle strength, speed, and steadiness, plus two brain signal measures, using special equipment. The investigators will also check if stronger brain signals lead to better muscle performance, especially in women. Our goal is to show that this new method strengthens thigh muscles better than standard rehab, helping women recover better after surgery. If successful, this could improve physical therapy for women recovering from ACL surgery, making daily activities and return to sport easier.
Primary Outcome
Peak torque during a 5 second maximal voluntary isometric contraction
Conditions Studied
Interventions
- DEVICE active transcranial direct current stimulation (tDCS)
- DEVICE sham transcranial direct current stimulation (tDCS)
Study Locations (1)
Pennsylvania
- Ryan Zarzycki - Glenside
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2025-06-05 |
| Est. Completion | 2028-06-04 |
| Phase | Phase 1 |
What NCT07128602 shows while recruiting
NCT07128602 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 42 participants, a relatively small participant target, above the 37-participant average among 4 other Anterior Cruciate Ligament Reconstruction Rehabilitation trials with a reported enrollment target (14% higher).
The record links to 2 conditions, with Anterior Cruciate Ligament Reconstruction Rehabilitation appearing as the primary indexed condition, and to 2 interventions - of which active transcranial direct current stimulation (tDCS) is the first listed.
NCT07128602 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT07128602 about?
NCT07128602 is a clinical study titled "Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction". After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, ag...
What is the current status of trial NCT07128602?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 42 participants. The study started on 2025-06-05. Estimated completion is 2028-06-04.
What conditions does trial NCT07128602 study?
This clinical trial studies the following conditions: Anterior Cruciate Ligament Reconstruction Rehabilitation, Quadriceps Muscle Function.
What interventions are being tested in trial NCT07128602?
The interventions under investigation include: active transcranial direct current stimulation (tDCS) (DEVICE), sham transcranial direct current stimulation (tDCS) (DEVICE).
Who is sponsoring clinical trial NCT07128602?
This trial is sponsored by Arcadia University, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07128602 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anterior Cruciate Ligament Reconstruction Rehabilitation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation
RECRUITING · NA
-
ACL Reconstruction Rehabilitation With Exercise and Psychological Support
RECRUITING · NA
-
Evaluation of Home-based Telerehabilitation Platform to Augment Orthopedic Rehabilitation
RECRUITING · NA
-
BFRT MPFL and ACL Reconstruction Rehab
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02852213 · 42 participants · Phase 1
A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients
- NCT03136146 · 42 participants · Phase 2
Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia
- NCT03178149 · 42 participants · Phase 1
A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
- NCT03663530 · 42 participants · NA
Circadian Misalignment and Energy Balance
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI