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RECRUITING Phase 1

Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction

NCT07128602 · View on ClinicalTrials.gov ↗

Study Summary

After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, the investigators measure thigh muscle strength, speed, and steadiness, plus two brain signal measures, using special equipment. The investigators will also check if stronger brain signals lead to better muscle performance, especially in women. Our goal is to show that this new method strengthens thigh muscles better than standard rehab, helping women recover better after surgery. If successful, this could improve physical therapy for women recovering from ACL surgery, making daily activities and return to sport easier.

Interventions

  • DEVICE active transcranial direct current stimulation (tDCS)
  • DEVICE sham transcranial direct current stimulation (tDCS)

Study Locations (1)

Pennsylvania

  • Ryan Zarzycki — Glenside

Trial Details

FieldValue
Enrollment Target 42 participants
Start Date 2025-06-05
Est. Completion 2028-06-04
Phase Phase 1

Sponsor

Arcadia University

32 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07128602

The ClinicalTrials.gov registry entry for NCT07128602 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arcadia University, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Anterior Cruciate Ligament Reconstruction Rehabilitation appearing as the primary indexed condition, and to 2 interventions — of which active transcranial direct current stimulation (tDCS) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07128602 reports 1 study location spanning 1 distinct geographic area — top geographies include Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07128602 about?

NCT07128602 is a clinical study titled "Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction". After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, ag...

What is the current status of trial NCT07128602?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 42 participants. The study started on 2025-06-05. Estimated completion is 2028-06-04.

What conditions does trial NCT07128602 study?

This clinical trial studies the following conditions: Anterior Cruciate Ligament Reconstruction Rehabilitation, Quadriceps Muscle Function. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07128602?

The interventions under investigation include: active transcranial direct current stimulation (tDCS) (DEVICE), sham transcranial direct current stimulation (tDCS) (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07128602?

This trial is sponsored by Arcadia University, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07128602 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial