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NCT07128602 · ClinicalTrials.gov registry record · Phase 1

Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction

A Phase 1 study of Anterior Cruciate Ligament Reconstruction Rehabilitation and Quadriceps Muscle Function, sponsored by Arcadia University.

Recruiting
Registry status
Phase 1
Development phase
42
Enrollment target
1
Study location

NCT07128602 is a Phase 1 study of Anterior Cruciate Ligament Reconstruction Rehabilitation and Quadriceps Muscle Function that is actively recruiting participants, run by Arcadia University. The registered enrollment target is 42 participants, above the 37-participant average among 4 other Anterior Cruciate Ligament Reconstruction Rehabilitation trials with a reported enrollment target (14% higher). The trial reports 1 study location across 1 state.

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The verdict

NCT07128602, a Phase 1 study of Anterior Cruciate Ligament Reconstruction Rehabilitation and Quadriceps Muscle Function, is actively recruiting participants, sponsored by Arcadia University.

RECRUITING
Registry status
Phase 1
Development phase
42 participants
Enrollment target
1
Study location

Study Summary

After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, the investigators measure thigh muscle strength, speed, and steadiness, plus two brain signal measures, using special equipment. The investigators will also check if stronger brain signals lead to better muscle performance, especially in women. Our goal is to show that this new method strengthens thigh muscles better than standard rehab, helping women recover better after surgery. If successful, this could improve physical therapy for women recovering from ACL surgery, making daily activities and return to sport easier.

Conditions Studied

Anterior Cruciate Ligament Reconstruction Rehabilitation Quadriceps Muscle Function

Interventions

  • DEVICE active transcranial direct current stimulation (tDCS)
  • DEVICE sham transcranial direct current stimulation (tDCS)

Study Locations (1)

Pennsylvania

  • Ryan Zarzycki - Glenside

Trial Details

FieldValue
Enrollment Target 42 participants
Start Date 2025-06-05
Est. Completion 2028-06-04
Phase Phase 1

Sponsor

Arcadia University

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07128602

The ClinicalTrials.gov registry entry for NCT07128602 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 37-participant average among 4 other Anterior Cruciate Ligament Reconstruction Rehabilitation trials with a reported enrollment target (14% higher). The listed sponsor is Arcadia University, which has 3 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Anterior Cruciate Ligament Reconstruction Rehabilitation appearing as the primary indexed condition, and to 2 interventions - of which active transcranial direct current stimulation (tDCS) is the first listed.

NCT07128602 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT07128602 about?

NCT07128602 is a clinical study titled "Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction". After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, ag...

What is the current status of trial NCT07128602?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 42 participants. The study started on 2025-06-05. Estimated completion is 2028-06-04.

What conditions does trial NCT07128602 study?

This clinical trial studies the following conditions: Anterior Cruciate Ligament Reconstruction Rehabilitation, Quadriceps Muscle Function.

What interventions are being tested in trial NCT07128602?

The interventions under investigation include: active transcranial direct current stimulation (tDCS) (DEVICE), sham transcranial direct current stimulation (tDCS) (DEVICE).

Who is sponsoring clinical trial NCT07128602?

This trial is sponsored by Arcadia University, which has 3 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07128602 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.