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NCT07099599 · ClinicalTrials.gov registry record
Image Detection of Impaired Microcirculatory Reperfusion
A clinical trial of Large Vessel Occlusion and Ischemic Stroke, Acute, sponsored by University of Cincinnati.
- Recruiting
- Registry status
- 40
- Enrollment target
- 1
- Study location
NCT07099599: Recruiting study of Large Vessel Occlusion and Ischemic Stroke, Acute, sponsored by University of Cincinnati.
NCT07099599 is a study of Large Vessel Occlusion and Ischemic Stroke, Acute that is actively recruiting participants, run by University of Cincinnati. The registered enrollment target is 40 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07099599, a study of Large Vessel Occlusion and Ischemic Stroke, Acute, is actively recruiting participants, sponsored by University of Cincinnati.
- RECRUITING
- Registry status
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain. These blood clots interrupt the normal flow of blood and oxygen to the nerve cells in the brain. When this occurs, the nerve cells can die, causing permanent damage to that area of the brain. That damage can result in loss of normal function to a patient's vision, strength, sensation, balance, or speech. These changes can remain permanent if blood flow is not restored to the brain. Thankfully, there are treatments available to help get rid of these blood clots. One of these treatments is a procedure to physically remove the blood clot causing stroke. This practice is now routinely done at all major stroke centers. Special imaging for stroke is now available at these major stroke centers. This imaging looks at blood flow in and around the area of brain that is dying. By performing these scans after the procedure, we can see that not all of brain is being saved by the procedure. That is a problem, because we know that saving brain cells can make a big difference in how patients recover from stroke. The purpose of this study is to determine which brain tissue will not get saved by blood clot removal. We will do this by using specialized imaging after the procedure. The study will discover if there is more brain tissue that can be saved after the procedure. Once we can determine this, our next steps will be looking at ways to save this tissue in the studies that follow. For example, we will look to see if medications can be given after the procedure to help save those brain areas. This study lays the groundwork for future studies to help save all the brain tissue we possibly can from dying during the stroke. This is our best chance of getting all patients affected by stroke the opportunity to live their best lives after stroke.
Primary Outcome
The primary outcome is feasibility determined by greater than or equal to 80% of the planned sample size for whom technically adequate 90-minute CTP and 48-96 hour MRI key parameters (baseline penumbra volume \[Tmax greater than 4 seconds\], predicted infarct core volume \[CBF greater than 30%\], and follow-up infarct volume \[MRI DWI\]) are usable.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST CT Perfusion
Study Locations (1)
Ohio
- University of Cincinnati - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-09-30 |
| Est. Completion | 2027-03-31 |
What NCT07099599 shows while recruiting
NCT07099599 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target.
The record links to 2 conditions, with Large Vessel Occlusion appearing as the primary indexed condition, and to 1 intervention - of which CT Perfusion is the first listed.
NCT07099599 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07099599 about?
NCT07099599 is a clinical study titled "Image Detection of Impaired Microcirculatory Reperfusion". Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain. These blood clots interrupt the normal flow of blood and oxygen to the nerve cells in the brain. When this occurs, the nerve cells can die, caus...
What is the current status of trial NCT07099599?
This trial is currently recruiting. The enrollment target is 40 participants. The study started on 2024-09-30. Estimated completion is 2027-03-31.
What conditions does trial NCT07099599 study?
This clinical trial studies the following conditions: Large Vessel Occlusion, Ischemic Stroke, Acute.
What interventions are being tested in trial NCT07099599?
The interventions under investigation include: CT Perfusion (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07099599?
This trial is sponsored by University of Cincinnati, which has 245 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07099599 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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