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NCT07091422 · ClinicalTrials.gov registry record · NA
A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive
A NA study of Orthodontic Treatment and Bracket Bonding, sponsored by University of Maryland, Baltimore.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07091422: Recruiting NA study of Orthodontic Treatment and Bracket Bonding, sponsored by University of Maryland, Baltimore.
NCT07091422 is a NA study of Orthodontic Treatment and Bracket Bonding that is actively recruiting participants, run by University of Maryland, Baltimore. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07091422, a NA study of Orthodontic Treatment and Bracket Bonding, is actively recruiting participants, sponsored by University of Maryland, Baltimore.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This randomized, split-mouth clinical trial will evaluate a new orthodontic adhesive that eliminates the need for acid etching before bracket bonding. Conventional orthodontic bonding requires etching enamel with phosphoric acid, which can weaken the outer enamel layer and increase the risk of white spot lesions and enamel damage. The etch-free adhesive under investigation is designed to simplify the bonding procedure while preserving enamel integrity. Twenty orthodontic patients starting treatment with braces will participate. For each patient, one side of the mouth (left or right) will be randomly assigned to receive the etch-free adhesive, while the opposite side will receive the conventional adhesive with acid etching. This intra-patient design allows a direct comparison under identical oral conditions. Participants will be followed for 12 months. Bracket failures, bonding time, ease of adhesive removal, enamel surface condition after debonding, and the presence of white spot lesions will be recorded. If effective, the etch-free adhesive may reduce enamel damage without compromising bond strength, providing a safer and more efficient bonding option for orthodontic patients.
Primary Outcome
The proportion of brackets bonded with each adhesive (etch-free vs. conventional) that experience bond failure over a 12-month follow-up period. A bond failure is defined as a clinically detached bracket requiring rebonding.
Conditions Studied
Interventions
- DEVICE Etch-Free Adhesive
- DEVICE Conventional Etch-and-Bond Adhesive
Study Locations (1)
Maryland
- University of Maryland Baltimore School of Dentistry - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-11-05 |
| Est. Completion | 2026-12-01 |
| Phase | NA |
What NCT07091422 shows while recruiting
NCT07091422 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 4 conditions, with Orthodontic Treatment appearing as the primary indexed condition, and to 2 interventions - of which Etch-Free Adhesive is the first listed.
NCT07091422 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT07091422 about?
NCT07091422 is a clinical study titled "A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive". This randomized, split-mouth clinical trial will evaluate a new orthodontic adhesive that eliminates the need for acid etching before bracket bonding. Conventional orthodontic bonding requires etching enamel with phosphoric acid, which can weaken the outer enamel layer and increase the risk of white...
What is the current status of trial NCT07091422?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2025-11-05. Estimated completion is 2026-12-01.
What conditions does trial NCT07091422 study?
This clinical trial studies the following conditions: Orthodontic Treatment, Bracket Bonding, Dental Adhesives/Restorations Performance, White Spot Lesion of Tooth.
What interventions are being tested in trial NCT07091422?
The interventions under investigation include: Etch-Free Adhesive (DEVICE), Conventional Etch-and-Bond Adhesive (DEVICE).
Who is sponsoring clinical trial NCT07091422?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07091422 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07091422's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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