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NCT07069426 · ClinicalTrials.gov registry record · NA
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
A NA study of Muscle Disuse and Muscle Disuse Atrophy, sponsored by United States Army Research Institute of Environmental Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 28
- Enrollment target
- 1
- Study location
NCT07069426 is a NA study of Muscle Disuse and Muscle Disuse Atrophy that is actively recruiting participants, run by United States Army Research Institute of Environmental Medicine. The registered enrollment target is 28 participants. The trial reports 1 study location across 1 state.
The verdict
NCT07069426, a NA study of Muscle Disuse and Muscle Disuse Atrophy, is actively recruiting participants, sponsored by United States Army Research Institute of Environmental Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 28 participants
- Enrollment target
- 1
- Study location
Study Summary
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy). Loss of muscle under these conditions is attributed to a persistent negative net muscle protein balance (muscle protein synthesis \[MPS\] \< muscle protein breakdown) that results, in part, from declines in postprandial MPS (i.e., anabolic resistance). Nutritional interventions that enhance postprandial MPS may be used to overcome disuse-induced anabolic resistance and preserve muscle mass to accelerate recovery and improve recovery outcomes. While supplemental protein has been explored as a potential countermeasure to disuse-induce anabolic resistance, the observed efficacy of such interventions has been mixed. Equivocal findings across studies may be attributed, in part, to an insufficient understanding of what constitutes an effective protein-based intervention. Importantly, no study to date has determined an optimal protein dose for overcoming disuse-induce anabolic resistance, or if there is a threshold for maximally stimulating postprandial MPS under disuse conditions. Therefore, the objective of this work is to determine rates of MPS at rest and in response to standard (20 g) or high (40 g) doses of whey protein during knee immobilization (DISUSE) compared with standard activity (ACTIVE)
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT 20 grams protein
- DIETARY_SUPPLEMENT 40 grams protein
Study Locations (1)
Massachusetts
- US Army Research Institute of Environmental Medicine - Natick
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2026-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07069426
The ClinicalTrials.gov registry entry for NCT07069426 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 28 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is United States Army Research Institute of Environmental Medicine, which has 59 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Muscle Disuse appearing as the primary indexed condition, and to 2 interventions - of which 20 grams protein is the first listed.
NCT07069426 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07069426 about?
NCT07069426 is a clinical study titled "Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization". Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy). Loss of muscle under these conditions is attributed to a persistent negative net muscle protein balance (...
What is the current status of trial NCT07069426?
This trial is currently recruiting. It is a NA study. The enrollment target is 28 participants. The study started on 2025-09-01. Estimated completion is 2026-09.
What conditions does trial NCT07069426 study?
This clinical trial studies the following conditions: Muscle Disuse, Muscle Disuse Atrophy.
What interventions are being tested in trial NCT07069426?
The interventions under investigation include: 20 grams protein (DIETARY_SUPPLEMENT), 40 grams protein (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07069426?
This trial is sponsored by United States Army Research Institute of Environmental Medicine, which has 59 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07069426 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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