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NCT07008989 · ClinicalTrials.gov registry record · NA
A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome
A NA study of Memory Replay and HippoCamera, sponsored by Boston College.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07008989: Recruiting NA study of Memory Replay and HippoCamera, sponsored by Boston College.
NCT07008989 is a NA study of Memory Replay and HippoCamera that is actively recruiting participants, run by Boston College. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07008989, a NA study of Memory Replay and HippoCamera, is actively recruiting participants, sponsored by Boston College.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory. In other words, individuals with Down syndrome may have a particular difficulty remembering specific details from past events. One way this manifests itself is in overgeneral autobiographical memory, or a tendency to remember the general gist of an event or cluster of events, rather than a single, isolated event. This overgeneral memory makes it difficult for individuals with Down syndrome to access their past, can interfere with attempts to becoming more independent, and increases anxiety and depression. In the current VIRTUAL study, the investigators test whether a new digital memory prosthetic-HippoCamera-can enhance specific autobiographical memory in individuals with Down syndrome. In HippoCamera, users are asked to record and replay events from their daily lives. This replay is curated by a research-based algorithm in HippoCamera that optimizes consolidation of these events over time and has been shown to enhance memory specificity in other populations with memory impairments, particularly those that stem from hippocampal disfunction. It is, therefore, likely that similar enhancements in autobiographical memory specificity will be identified in individuals with Down syndrome, highlighting the benefits of this applications in this population.
Primary Outcome
All memory narratives will be transcribed and scored using the Autobiographical Interview protocol. Highly trained raters will score each autobiographical memory according to the number and proportion of episodic (internal) vs. semantic (external) details. Episodic details are specific to the time and place of the targeted event, whereas semantic details involve factual information or extended events that do not require recollection of a specific time and place. Memory for episodic details requ
Conditions Studied
Interventions
- BEHAVIORAL Memory replay
Study Locations (1)
Massachusetts
- Boston College ONLINE STUDY - Chestnut Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-06-01 |
| Est. Completion | 2026-07-31 |
| Phase | NA |
What NCT07008989 shows while recruiting
NCT07008989 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Memory Replay appearing as the primary indexed condition, and to 1 intervention - of which Memory replay is the first listed.
NCT07008989 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07008989 about?
NCT07008989 is a clinical study titled "A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome". Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory. In other words, individuals with Down syndrome may have a particular difficulty remembering specific details from...
What is the current status of trial NCT07008989?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-06-01. Estimated completion is 2026-07-31.
What conditions does trial NCT07008989 study?
This clinical trial studies the following conditions: Memory Replay, HippoCamera.
What interventions are being tested in trial NCT07008989?
The interventions under investigation include: Memory replay (BEHAVIORAL).
Who is sponsoring clinical trial NCT07008989?
This trial is sponsored by Boston College, which has 18 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07008989 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07008989's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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