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NCT06941467 · ClinicalTrials.gov registry record · Phase 1
Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds
A Phase 1 study of Wound Healing and Mohs Micrographic Surgery, sponsored by Icahn School of Medicine at Mount Sinai.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 102
- Enrollment target
- 1
- Study location
NCT06941467 is a Phase 1 study of Wound Healing and Mohs Micrographic Surgery that is actively recruiting participants, run by Icahn School of Medicine at Mount Sinai. The registered enrollment target is 102 participants, above the 48-participant average among 11 other Wound Healing trials with a reported enrollment target (113% higher). The trial reports 1 study location across 1 state.
The verdict
NCT06941467, a Phase 1 study of Wound Healing and Mohs Micrographic Surgery, is actively recruiting participants, sponsored by Icahn School of Medicine at Mount Sinai.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 102 participants
- Enrollment target
- 1
- Study location
Study Summary
Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in wound healing over the past several years. The majority of the literature has evaluated the use of topical timolol to shorten wound healing time in chronic wounds of non-surgical etiologies. To date, there are no prospective randomized clinical trials evaluating the role of topical timolol for shortening wound healing time in acute open surgical wounds. Therefore, the purpose of this study is to determine whether or not topical timolol solution decreases time to wound healing in patients with defects after Mohs Micrographic Surgery (MMS) that cannot be closed with sutures and are left to heal by second intent. The research team also will look to determine if there is a difference in cosmesis of wounds treated with topical timolol compared to those treated with the standard of care. The present study will primarily focus on wounds in the distal lower extremity as these are most commonly left to heal by secondary intent
Conditions Studied
Interventions
- OTHER Standard of Care
- DRUG Timolol Maleate Solution
Study Locations (1)
New York
- Mount Sinai - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2025-01-03 |
| Est. Completion | 2026-04-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06941467
The ClinicalTrials.gov registry entry for NCT06941467 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 102 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 48-participant average among 11 other Wound Healing trials with a reported enrollment target (113% higher). The listed sponsor is Icahn School of Medicine at Mount Sinai, which has 708 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Wound Healing appearing as the primary indexed condition, and to 2 interventions - of which Standard of Care is the first listed.
NCT06941467 reports 1 study location spanning 1 distinct geographic area - top geographies include New York.
Frequently Asked Questions
What is clinical trial NCT06941467 about?
NCT06941467 is a clinical study titled "Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds". Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in wound healing over the past several years. The majority of the literature has evaluated the use of topical timolol to shorten wound healing time in chronic wounds of non-surgical etiologies. To date, there are n...
What is the current status of trial NCT06941467?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 102 participants. The study started on 2025-01-03. Estimated completion is 2026-04-01.
What conditions does trial NCT06941467 study?
This clinical trial studies the following conditions: Wound Healing, Mohs Micrographic Surgery.
What interventions are being tested in trial NCT06941467?
The interventions under investigation include: Standard of Care (OTHER), Timolol Maleate Solution (DRUG).
Who is sponsoring clinical trial NCT06941467?
This trial is sponsored by Icahn School of Medicine at Mount Sinai, which has 708 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06941467 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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