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NCT06896916 · ClinicalTrials.gov registry record · Phase 1
Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma
A Phase 1 study of Multiple Myeloma, sponsored by AbbVie.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 135
- Enrollment target
- 20
- Study locations
NCT06896916: Recruiting Phase 1 study of Multiple Myeloma, sponsored by AbbVie.
NCT06896916 is a Phase 1 study of Multiple Myeloma that is actively recruiting participants, run by AbbVie. The registered enrollment target is 135 participants, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (75% lower). The trial reports 20 study locations across 18 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06896916, a Phase 1 study of Multiple Myeloma, is actively recruiting participants, sponsored by AbbVie.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 135 participants
- Enrollment target
- 20
- Study locations
Study Summary
Multiple myeloma (MM) is a plasma cell disease characterized by the growth of clonal plasma cells in the bone marrow. The purpose of this study is to assess the adverse events and change in disease activity of etentamig in combination with a cereblon E3 ligase modulatory drug (CELMoD) agent in adult participants with relapsed/refractory (R/R) multiple myeloma (MM). Adverse events and change in disease state will be assessed. Etentamig is an investigational drug being developed for the treatment of R/R MM. Study doctors put the participants in groups called treatment arms. Multiple doses of etentamig in combination with iberdomide will be explored. Each treatment arm receives a different dose of etentamig and iberdomide to determine a tolerable dose. Approximately 135 adult participants with R/R MM will be enrolled in the study in approximately 50 sites worldwide. In phase 1 participants will receive escalating intravenous (IV) etentamig in combination with oral iberdomide. In phase 2 participants will receive IV etentamig at one of two doses in combination with oral iberdomide, as part of the approximately 129 month study duration. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and and monitoring of side effects.
Conditions Studied
Interventions
- DRUG Iberdomide
- DRUG Etentamig
Study Locations (20)
New South Wales
- Blacktown Hospital /ID# 265983 - Blacktown
- Wollongong Hospital /ID# 265625 - Wollongong
Victoria
- The Alfred Hospital /ID# 265981 - Melbourne
- Austin Hospital /ID# 265984 - Melbourne
California
- Beverly Hills Cancer Center /ID# 266921 - Beverly Hills
Colorado
- Colorado Blood Cancer Institute /ID# 273751 - Denver
Missouri
- Washington University /ID# 266972 - St Louis
New Jersey
- Rutgers Cancer Institute of New Jersey /ID# 266833 - New Brunswick
New York
- Memorial Sloan Kettering Cancer Center - New York - York Avenue /ID# 270282 - New York
North Carolina
- University Of North Carolina Health Care - Hillsborough Campus /ID# 278230 - Hillsborough
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 135 participants |
| Start Date | 2025-08-07 |
| Est. Completion | 2036-03 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06896916
The ClinicalTrials.gov registry entry for NCT06896916 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 135 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (75% lower). The listed sponsor is AbbVie, which has 526 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions - of which Iberdomide is the first listed.
NCT06896916 reports 20 study locations spanning 18 distinct geographic areas - top geographies include New South Wales, Victoria, California.
Frequently Asked Questions
What is clinical trial NCT06896916 about?
NCT06896916 is a clinical study titled "Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma". Multiple myeloma (MM) is a plasma cell disease characterized by the growth of clonal plasma cells in the bone marrow. The purpose of this study is to assess the adverse events and change in disease activity of etentamig in combination with a cereblon E3 ligase modulatory drug (CELMoD) agent in adult...
What is the current status of trial NCT06896916?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 135 participants. The study started on 2025-08-07. Estimated completion is 2036-03.
What conditions does trial NCT06896916 study?
This clinical trial studies the following conditions: Multiple Myeloma.
What interventions are being tested in trial NCT06896916?
The interventions under investigation include: Iberdomide (DRUG), Etentamig (DRUG).
Who is sponsoring clinical trial NCT06896916?
This trial is sponsored by AbbVie, which has 526 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06896916 being conducted?
This trial has 20 study locations across California, Colorado, Missouri, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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