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VY7523-102: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study in Participants With Early Alzheimer's Disease
NCT06874621 · View on ClinicalTrials.gov ↗
Study Summary
This study is to be conducted in participants with early Alzheimer's Disease to test VY7523, a new drug being researched for treatment of Alzheimer's Disease. This study will look at how safe the drug is and how it works in the brain. It was first tested in normal, healthy participants who volunteered to participate. The study will look at three different dose levels, starting with the lowest dose first and moving to higher doses and more participants after safety has been reviewed by doctors and researchers. Some patients will receive drug while others will receive placebo. This will help to better compare how the drug works between participants receiving drug and placebo. The study will last up to 6 months for the lower dose groups and 12 months for the highest dose group.
Conditions Studied
Interventions
- DRUG Placebo Comparator
- DRUG VY7523
Study Locations (20)
Florida
- VYGR Site 840005 — Delray Beach
- VYGR Site 840021 — Fort Myers
- VYGR Site 840010 — Lady Lake
- VYGR Site 840015 — Miami
- VYGR Site 840014 — Miami
- VYGR Site 840024 — Miami
- VYGR Site 840006 — Orlando
- VYGR Site 840003 — Stuart
- VYGR Site 840004 — The Villages
- VYGR Site 840002 — Wellington
- VYGR Site 840020 — Winter Park
California
- VYGR Site 840018 — Los Angeles
- VYGR Site 840016 — Orange
- VYGR Site 840022 — San Francisco
Connecticut
- VYGR Site 840008 — Stamford
Georgia
- VYGR Site 840007 — Decatur
New Jersey
- VYGR Site 840012 — Toms River
North Carolina
- VYGR Site 840009 — Matthews
Pennsylvania
- VYGR Site 840011 — Plymouth Meeting
Ontario
- VYGR Site 124002 — Ottawa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2025-03-03 |
| Est. Completion | 2027-05 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06874621
The ClinicalTrials.gov registry entry for NCT06874621 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 52 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Voyager Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Alzheimer's Disease (AD) appearing as the primary indexed condition, and to 2 interventions — of which Placebo Comparator is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06874621 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Florida, California, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06874621 about?
NCT06874621 is a clinical study titled "VY7523-102: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study in Participants With Early Alzheimer's Disease". This study is to be conducted in participants with early Alzheimer's Disease to test VY7523, a new drug being researched for treatment of Alzheimer's Disease. This study will look at how safe the drug is and how it works in the brain. It was first tested in normal, healthy participants who volunteer...
What is the current status of trial NCT06874621?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 52 participants. The study started on 2025-03-03. Estimated completion is 2027-05.
What conditions does trial NCT06874621 study?
This clinical trial studies the following conditions: Alzheimer's Disease (AD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06874621?
The interventions under investigation include: Placebo Comparator (DRUG), VY7523 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06874621?
This trial is sponsored by Voyager Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06874621 being conducted?
This trial has 20 study locations across California, Connecticut, Florida, Georgia, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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