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NCT06874283 · ClinicalTrials.gov registry record
Ocular Complications From Cancer Therapy - Patient Registry and Biobank
A clinical trial of Graft Versus Host Disease in Eye and Ocular Complications, sponsored by University of Maryland, Baltimore.
- Recruiting
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT06874283: Recruiting study of Graft Versus Host Disease in Eye and Ocular Complications, sponsored by University of Maryland, Baltimore.
NCT06874283 is a study of Graft Versus Host Disease in Eye and Ocular Complications that is actively recruiting participants, run by University of Maryland, Baltimore. The registered enrollment target is 150 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06874283, a study of Graft Versus Host Disease in Eye and Ocular Complications, is actively recruiting participants, sponsored by University of Maryland, Baltimore.
- RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to collect data on patients seen at University of Maryland after undergoing cancer therapy. Previous medications, ocular history, medical history, clinical evaluations, surgical procedures and outcomes will be gathered on the patients who consent to participate. Potential subjects will be enrolled from the clinical practice of the investigator at the time of their eye examination visit. A standard of care exam will be performed pertinent to the reason for the visit. In addition to the standard of care exam, certain biological specimens (ocular surface wash, mucocellular material, corneal filaments, impression cytology, and/or blood) will be collected, stored, and analyzed to obtain immunologic, cellular, or molecular mechanistic insights into disease pathogenesis.
Primary Outcome
The International Chronic oGVHD severity score (Ogawa, Y. et al. International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I). Sci Rep 3, 3419 (2013). https://doi.org/10.1038/srep03419) is the standard of care for diagnosing and monitoring ocular GvHD. Briefly, this is calculated based on the sum of the patient's Schirmer's severity score (range of 0-3), OSDI severity score (range of 0-3), corneal fluorescein staining severity
Conditions Studied
Interventions
- PROCEDURE Eye exam
Study Locations (1)
Maryland
- Stoler Outpatient Cancer Center at the University of Maryland - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2025-05-13 |
| Est. Completion | 2031-04 |
What NCT06874283 shows while recruiting
NCT06874283 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap.
The record links to 3 conditions, with Graft Versus Host Disease in Eye appearing as the primary indexed condition, and to 1 intervention - of which Eye exam is the first listed.
NCT06874283 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06874283 about?
NCT06874283 is a clinical study titled "Ocular Complications From Cancer Therapy - Patient Registry and Biobank". The purpose of this study is to collect data on patients seen at University of Maryland after undergoing cancer therapy. Previous medications, ocular history, medical history, clinical evaluations, surgical procedures and outcomes will be gathered on the patients who consent to participate. Potentia...
What is the current status of trial NCT06874283?
This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2025-05-13. Estimated completion is 2031-04.
What conditions does trial NCT06874283 study?
This clinical trial studies the following conditions: Graft Versus Host Disease in Eye, Ocular Complications, Inflammatory Dry Eye Disease.
What interventions are being tested in trial NCT06874283?
The interventions under investigation include: Eye exam (PROCEDURE).
Who is sponsoring clinical trial NCT06874283?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06874283 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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