Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
NCT06863272 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this substudy is to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd), given alone or with other treatments in participants with metastatic castration-resistant prostate cancer (mCRPC). The goals of this study are to learn about: * The safety of the study treatment and if people tolerate it. * A safe dose level of I-DXd that can be used with other treatments. * Participant levels of prostate specific antigen (PSA) during treatment.
Conditions Studied
Interventions
- DRUG Docetaxel
- DRUG Enzalutamide
- DRUG Abiraterone
- DRUG Ifinatamab Deruxtecan
- DRUG MK-5684
Study Locations (20)
Other
- Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0200) — La Rioja
- IPITEC ( Site 0275) — São Paulo
- IBCC - Instituto Brasileiro de Controle do Câncer ( Site 0269) — São Paulo
São Paulo
- Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0268) — Bragança Paulista
- Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0263) — São José do Rio Preto
- Hospital Alemao Oswaldo Cruz ( Site 0279) — São Paulo
Rio Grande do Sul
- Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0270) — Porto Alegre
- Hospital Moinhos de Vento ( Site 0278) — Porto Alegre
Ontario
- Sunnybrook Research Institute ( Site 0109) — Toronto
- Princess Margaret Cancer Centre ( Site 0102) — Toronto
California
- UCSF Medical Center at Mission Bay ( Site 0034) — San Francisco
District of Columbia
- MedStar Georgetown Cancer Institute at MedStar Washington Hospital Center ( Site 0026) — Washington D.C.
Pennsylvania
- UPMC Hillman Cancer Center ( Site 0014) — Pittsburgh
Tennessee
- The West Clinic, PLLC dba West Cancer Center ( Site 0005) — Germantown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 360 participants |
| Start Date | 2025-07-03 |
| Est. Completion | 2030-02-24 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06863272
The ClinicalTrials.gov registry entry for NCT06863272 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 360 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Metastasis appearing as the primary indexed condition, and to 5 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06863272 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Other, São Paulo, Rio Grande do Sul. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06863272 about?
NCT06863272 is a clinical study titled "A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)". The purpose of this substudy is to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd), given alone or with other treatments in participants with metastatic castration-resistant prostate cancer (mCRPC). The goals of this study are to learn about: * The safety of the study treatment and ...
What is the current status of trial NCT06863272?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 360 participants. The study started on 2025-07-03. Estimated completion is 2030-02-24.
What conditions does trial NCT06863272 study?
This clinical trial studies the following conditions: Metastasis, Castration-Resistant Prostatic Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06863272?
The interventions under investigation include: Docetaxel (DRUG), Enzalutamide (DRUG), Abiraterone (DRUG), Ifinatamab Deruxtecan (DRUG), MK-5684 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06863272?
This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06863272 being conducted?
This trial has 20 study locations across California, District of Columbia, Pennsylvania, Tennessee, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.