Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06846320 · ClinicalTrials.gov registry record · Phase 2
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
A Phase 2 study of Generalized Anxiety Disorder (GAD), sponsored by AbbVie.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 315
- Enrollment target
- 20
- Study locations
NCT06846320 is a Phase 2 study of Generalized Anxiety Disorder (GAD) that is actively recruiting participants, run by AbbVie. The registered enrollment target is 315 participants, above the 166-participant average among 6 other Generalized Anxiety Disorder (GAD) trials with a reported enrollment target (90% higher). The trial reports 20 study locations across 6 states.
The verdict
NCT06846320, a Phase 2 study of Generalized Anxiety Disorder (GAD), is actively recruiting participants, sponsored by AbbVie.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 315 participants
- Enrollment target
- 20
- Study locations
Study Summary
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants with GAD who have had an inadequate response ADTs. ABBV-932 is an investigational drug being developed for the adjunctive treatment of GAD. Participants will be randomly assigned to receive ABBV-932 or Placebo in addition to their currently prescribed ADTs. There is 1 in 3 chance of participants assigned to Placebo. Approximately 315 adult participants with GAD and inadequate response to ADTs will be enrolled in approximately 50 sites in the United States and Puerto Rico. Participants will receive oral capsules of ABBV-932 or matching placebo in addition to their prescribed ADT for 6 weeks and then will be followed for an additional 4 week follow-up period. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Conditions Studied
Interventions
- DRUG ABBV-932
- DRUG Placebo for ABBV-932
- DRUG Antidepressant Therapy (ADT)
Study Locations (20)
California
- Advanced Research Center /ID# 267874 - Anaheim
- Axiom Research /ID# 267814 - Colton
- Sun Valley Research Center /ID# 267864 - Imperial
- Synergy San Diego /ID# 267879 - Lemon Grove
- Alliance for Research Alliance for Wellness /ID# 267911 - Long Beach
- NRC Research Institute DTLA /ID# 267832 - Los Angeles
- Excell Research /ID# 267918 - Oceanside
- Viking Clinical Research Center - Temecula /ID# 268598 - Temecula
- Sunwise Clinical Research /ID# 267863 - Walnut Creek
Florida
- Cns Healthcare - Jacksonville /ID# 268588 - Jacksonville
- Accel Research Sites Network - St. Pete /ID# 267821 - Largo
- K2 Medical Research, LLC /ID# 267841 - Maitland
- GMI Florida - Central Miami Medical Institute /ID# 267839 - Miami
- Allied Biomedical Res Inst Inc /ID# 267813 - Miami
- Apg Research /ID# 271707 - Orlando
Arizona
- Ima Clinical Research Phoenix (Alea) /ID# 275737 - Phoenix
- Noble Clinical Research /ID# 267952 - Tucson
Alabama
- University of Alabama - Huntsville Regional Medical Campus /ID# 267818 - Huntsville
Connecticut
- Connecticut Clinical Research - Cromwell /ID# 271241 - Cromwell
Georgia
- Psych Atlanta /ID# 267878 - Marietta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 315 participants |
| Start Date | 2025-04-29 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06846320
The ClinicalTrials.gov registry entry for NCT06846320 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 315 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 166-participant average among 6 other Generalized Anxiety Disorder (GAD) trials with a reported enrollment target (90% higher). The listed sponsor is AbbVie, which has 526 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Generalized Anxiety Disorder (GAD) appearing as the primary indexed condition, and to 3 interventions - of which ABBV-932 is the first listed.
NCT06846320 reports 20 study locations spanning 6 distinct geographic areas - top geographies include California, Florida, Arizona.
Frequently Asked Questions
What is clinical trial NCT06846320 about?
NCT06846320 is a clinical study titled "Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder". Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants wi...
What is the current status of trial NCT06846320?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 315 participants. The study started on 2025-04-29. Estimated completion is 2026-11.
What conditions does trial NCT06846320 study?
This clinical trial studies the following conditions: Generalized Anxiety Disorder (GAD).
What interventions are being tested in trial NCT06846320?
The interventions under investigation include: ABBV-932 (DRUG), Placebo for ABBV-932 (DRUG), Antidepressant Therapy (ADT) (DRUG).
Who is sponsoring clinical trial NCT06846320?
This trial is sponsored by AbbVie, which has 526 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06846320 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Generalized Anxiety Disorder (GAD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Targeting Social Function in Anxiety and Eating Disorders
RECRUITING · NA
-
Stepped Care Treatment for Anxiety Resilience
RECRUITING · NA
-
Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder
RECRUITING · Phase 3
-
Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD
RECRUITING · NA
-
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ABBV-932 in Healthy Adult Participants, Participants With Generalized Anxiety Disorder (GAD) and Participants With Bipolar Disorder (BPD)
COMPLETED · Phase 1
-
EDG004 Treatment of Adult Patients With Generalized Anxiety Disorder (GAD)
COMPLETED · Phase 3
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.