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RECRUITING Phase 2

Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease

NCT06824987 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to assess the efficacy and safety of AZD2373 in participants diagnosed with APOL1-Mediated Kidney Disease (AMKD) who are homozygotes or compound heterozygotes for APOL1 high-risk genotypes (G1 and G2). The primary hypothesis to be evaluated is that AZD2373, compared with placebo, will result in a greater reduction in UACR as assessed by the relative change from Baseline in UACR at Week 30.

Interventions

  • COMBINATION_PRODUCT Placebo
  • COMBINATION_PRODUCT AZD2373-Arm 1
  • COMBINATION_PRODUCT AZD2373-Arm 2
  • DEVICE APOL1 Genotyping Clinical Trial Assay

Study Locations (20)

Georgia

  • Research Site — Atlanta
  • Research Site — Augusta
  • Research Site — Augusta
  • Research Site — Columbus
  • Research Site — Columbus
  • Research Site — Duluth
  • Research Site — Hinesville
  • Research Site — Lawrenceville

Florida

  • Research Site — Brandon
  • Research Site — Miami
  • Research Site — Miami
  • Research Site — Orlando
  • Research Site — Pompano Beach

California

  • Research Site — Beverly Hills
  • Research Site — Gardena
  • Research Site — Los Angeles
  • Research Site — Valencia

Alabama

  • Research Site — Alabaster
  • Research Site — Birmingham
  • Research Site — Irondale

Trial Details

FieldValue
Enrollment Target 96 participants
Start Date 2025-03-05
Est. Completion 2027-08-30
Phase Phase 2

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06824987

The ClinicalTrials.gov registry entry for NCT06824987 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 96 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with APOL1-Mediated Kidney Disease appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06824987 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Georgia, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06824987 about?

NCT06824987 is a clinical study titled "Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease". The purpose of this study is to assess the efficacy and safety of AZD2373 in participants diagnosed with APOL1-Mediated Kidney Disease (AMKD) who are homozygotes or compound heterozygotes for APOL1 high-risk genotypes (G1 and G2). The primary hypothesis to be evaluated is that AZD2373, compared with...

What is the current status of trial NCT06824987?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 96 participants. The study started on 2025-03-05. Estimated completion is 2027-08-30.

What conditions does trial NCT06824987 study?

This clinical trial studies the following conditions: APOL1-Mediated Kidney Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06824987?

The interventions under investigation include: Placebo (COMBINATION_PRODUCT), AZD2373-Arm 1 (COMBINATION_PRODUCT), AZD2373-Arm 2 (COMBINATION_PRODUCT), APOL1 Genotyping Clinical Trial Assay (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06824987?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06824987 being conducted?

This trial has 20 study locations across Alabama, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial