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NCT06817018 · ClinicalTrials.gov registry record · Phase 2

Ginger Root Extract for Sciatic Pain Individuals

A Phase 2 study of Neuropathic Pain and Sciatic Pain, sponsored by Leslie Shen.

Recruiting
Registry status
Phase 2
Development phase
80
Enrollment target
2
Study locations

NCT06817018 is a Phase 2 study of Neuropathic Pain and Sciatic Pain that is actively recruiting participants, run by Leslie Shen. The registered enrollment target is 80 participants, below the 99-participant average among 35 other Neuropathic Pain trials with a reported enrollment target (19% lower). The trial reports 2 study locations across 1 state.

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The verdict

NCT06817018, a Phase 2 study of Neuropathic Pain and Sciatic Pain, is actively recruiting participants, sponsored by Leslie Shen.

RECRUITING
Registry status
Phase 2
Development phase
80 participants
Enrollment target
2
Study locations

Study Summary

Neuropathic pain affects the quality of life of many Americans. Non-pharmacological strategies such as bioactive compounds in foods are being explored as therapeutics but can also serve as tools to better understand pain mechanisms. The previous study reported that ginger root extract supplementation palliated pain-spectrum behaviors in animals with neuropathic pain via the microbiota-gut-brain axis. The proposed study is primarily designed to use ginger supplementation for a better understanding of the role of microbiota-gut-brain interactions in sciatica states in a randomized, double-blinded, and placebo-controlled trial. Eighty participants with sciatica will be randomized to receive placebo (2000 mg starch daily) or ginger (2000 mg daily) for 8 weeks. This study will evaluate the effects of ginger supplementation on gut function measured as gut microbiota composition using 16S rRNA sequencing analysis, intestinal permeability based on plasma lipopolysaccharide binding protein and fecal zonulin using ELISA, and fecal metabolites using LC-MS/MS analysis (SA 1); on neuroinflammation in whole blood mRNA using nCounter® Neuroinflammation Panels analysis (SA 2); and on pain-associated outcomes and brain neuroplasticity by assessing functional (resting state-fMRI) and structural (Diffusion Tensor Imaging) connectivity (SA 3).

Conditions Studied

Neuropathic Pain Sciatic Pain

Interventions

  • DIETARY_SUPPLEMENT Placebo
  • DRUG Ginger

Study Locations (2)

Texas

  • Texas Tech University Health Sciences Center - Lubbock
  • Texas Tech University Health Sciences Center - Lubbock

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2025-07-01
Est. Completion 2028-02-28
Phase Phase 2

Sponsor

Leslie Shen

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06817018

The ClinicalTrials.gov registry entry for NCT06817018 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 99-participant average among 35 other Neuropathic Pain trials with a reported enrollment target (19% lower). The listed sponsor is Leslie Shen, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Neuropathic Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT06817018 reports 2 study locations spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT06817018 about?

NCT06817018 is a clinical study titled "Ginger Root Extract for Sciatic Pain Individuals". Neuropathic pain affects the quality of life of many Americans. Non-pharmacological strategies such as bioactive compounds in foods are being explored as therapeutics but can also serve as tools to better understand pain mechanisms. The previous study reported that ginger root extract supplementatio...

What is the current status of trial NCT06817018?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2025-07-01. Estimated completion is 2028-02-28.

What conditions does trial NCT06817018 study?

This clinical trial studies the following conditions: Neuropathic Pain, Sciatic Pain.

What interventions are being tested in trial NCT06817018?

The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Ginger (DRUG).

Who is sponsoring clinical trial NCT06817018?

This trial is sponsored by Leslie Shen, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06817018 being conducted?

This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.