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A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
NCT06806033 · View on ClinicalTrials.gov ↗
Study Summary
This Phase II trial evaluates the optimization of the cytokine release syndrome (CRS) profile for glofitamab in combination with gemcitabine and oxaliplatin (Glofit-GemOx) in participants with relapsed or refractory aggressive B-cell Non-Hodgkin's lymphoma. The study utilizes an optimized steroid premedication regimen and monitoring schedule specifically designed to enable the administration of the treatment regimen in an outpatient setting.
Conditions Studied
Interventions
- DRUG Obinutuzumab
- DRUG Glofitamab
- DRUG Oxaliplatin
- DRUG Gemcitabine
Study Locations (20)
California
- Community Cancer Institute (CCI) — Clovis
- Providence Medical Foundation — Fullerton
- Los Angeles Cancer Network — Glendale
- Valkyrie Clinical Trials — Los Angeles
- Zuckerberg San Francisco General Hospital — San Francisco
- The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente — Torrance
Florida
- North Florida/ South Georgia VA Medical Center — Gainesville
- Mount Sinai Comprehensive Cancer Center — Miami
- Orlando Health Cancer Institute — Orlando
New York
- New York Oncology Hematology, P.C. — Albany
- Hematology Oncology Associates of Central New York — East Syracuse
Alaska
- Alaska Oncology & Hematology, LLC — Anchorage
Colorado
- Rocky Mountain Cancer Centers, LLP — Aurora
Idaho
- St Luke?s Cancer Institute — Boise
Illinois
- Cancer Care Specialists of Central Illinois — Swansea
Iowa
- Mission Blood and Cancer - MercyOne Cancer Center — Waukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-03-05 |
| Est. Completion | 2029-03-30 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06806033
The ClinicalTrials.gov registry entry for NCT06806033 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with B-Cell Non-Hodgkins Lymphoma appearing as the primary indexed condition, and to 4 interventions — of which Obinutuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06806033 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Florida, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06806033 about?
NCT06806033 is a clinical study titled "A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma". This Phase II trial evaluates the optimization of the cytokine release syndrome (CRS) profile for glofitamab in combination with gemcitabine and oxaliplatin (Glofit-GemOx) in participants with relapsed or refractory aggressive B-cell Non-Hodgkin's lymphoma. The study utilizes an optimized steroid pr...
What is the current status of trial NCT06806033?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2025-03-05. Estimated completion is 2029-03-30.
What conditions does trial NCT06806033 study?
This clinical trial studies the following conditions: B-Cell Non-Hodgkins Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06806033?
The interventions under investigation include: Obinutuzumab (DRUG), Glofitamab (DRUG), Oxaliplatin (DRUG), Gemcitabine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06806033?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06806033 being conducted?
This trial has 20 study locations across Alaska, California, Colorado, Florida, Idaho. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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