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NCT06747715 · ClinicalTrials.gov registry record · NA
Autologous Fresh Fat Grafting Followed by Autologous Cryopreserved Fat Grafting
A NA study of Facial Defect, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 22
- Enrollment target
- 1
- Study location
NCT06747715: Recruiting NA study of Facial Defect, sponsored by University of Pittsburgh.
NCT06747715 is a NA study of Facial Defect that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 22 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06747715, a NA study of Facial Defect, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 22 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to validate the safety and effectiveness of a two-stage approach for minimally invasive craniofacial soft tissue reconstruction using autologous fat grafting in wounded service members and veterans. The main questions it aims to answer are: 1. Will treating subjects with post-traumatic craniofacial deformities using fresh fat grafts, followed by a second treatment 3 months later with cryopreserved fat stored at -80°C, improve facial tissue regeneration and appearance? 2. How do volume retention and tissue health change between fresh and cryopreserved grafts in humans? 3. How do factors such as cellular composition of the graft, patient demographics, and medical conditions (including diabetes, tobacco use, medications, age, and BMI) affect fat graft volume retention and overall outcomes? Researchers will compare results from the second-stage cryopreserved fat grafting to fresh fat grafting to assess outcomes like volume retention, patient recovery, and cost reduction. Participants will: Undergo an initial fat grafting procedure. Have additional fat harvested and cryo-stored for use in a second-stage procedure. Receive the cryopreserved fat in a later stage without the need for a second fat harvest. Receive small test injections behind each ear for later analysis. Provide data on demographics and medical conditions for correlation with outcomes.
Primary Outcome
This is a validated visual 3-point grading scale that will be scored by 4 blinded observers (2 physicians and 2 lay-observers) from standardized photographs The definitions for each of three points on the scale are listed here: a score of 1 means: for baseline grading of a given facial aesthetic region assessed there is an obvious contour defect that would benefit from volume fill. For post-treatment grading, no discernable improvement from baseline. A score of 2 means: for a given facial aesthe
Conditions Studied
Interventions
- PROCEDURE Serial Fat Grafting Fresh followed by Cryopreserved Fat
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2025-10-01 |
| Est. Completion | 2027-12-31 |
| Phase | NA |
What NCT06747715 shows while recruiting
NCT06747715 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Facial Defect appearing as the primary indexed condition, and to 1 intervention - of which Serial Fat Grafting Fresh followed by Cryopreserved Fat is the first listed.
NCT06747715 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06747715 about?
NCT06747715 is a clinical study titled "Autologous Fresh Fat Grafting Followed by Autologous Cryopreserved Fat Grafting". The goal of this clinical trial is to validate the safety and effectiveness of a two-stage approach for minimally invasive craniofacial soft tissue reconstruction using autologous fat grafting in wounded service members and veterans. The main questions it aims to answer are: 1. Will treating subjec...
What is the current status of trial NCT06747715?
This trial is currently recruiting. It is a NA study. The enrollment target is 22 participants. The study started on 2025-10-01. Estimated completion is 2027-12-31.
What conditions does trial NCT06747715 study?
This clinical trial studies the following conditions: Facial Defect.
What interventions are being tested in trial NCT06747715?
The interventions under investigation include: Serial Fat Grafting Fresh followed by Cryopreserved Fat (PROCEDURE).
Who is sponsoring clinical trial NCT06747715?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06747715 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06747715's enrollment target sits among peer trials
22 1756th of 2000 higher than 239 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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