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RECRUITING Phase 3

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

NCT06742723 · View on ClinicalTrials.gov ↗

Study Summary

International, Multicenter, Double-Blind, Placebo-Controlled and Event-driven study to assess efficacy, safety and Tolerability of Baxdrostat in combination with Dapagliflozin on renal outcomes and cardiovascular mortality in participants with chronic kidney disease and high blood pressure

Interventions

  • DRUG Baxdrostat/dapagliflozin
  • DRUG Placebo/dapagliflozin

Study Locations (20)

California

  • Research Site — Beverly Hills
  • Research Site — Canoga Park
  • Research Site — Concord
  • Research Site — Fremont
  • Research Site — Fullerton
  • Research Site — Inglewood
  • Research Site — Los Alamitos
  • Research Site — Los Angeles
  • Research Site — San Diego
  • Research Site — San Francisco
  • Research Site — Stanford
  • Research Site — Tarzana

Arizona

  • Research Site — Surprise
  • Research Site — Tucson

Colorado

  • Research Site — Arvada
  • Research Site — Denver

Alabama

  • Research Site — Fairhope

Connecticut

  • Research Site — New Britain

District of Columbia

  • Research Site — Washington D.C.

Florida

  • Research Site — Boca Raton

Trial Details

FieldValue
Enrollment Target 5,000 participants
Start Date 2025-03-03
Est. Completion 2029-12-18
Phase Phase 3

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06742723

The ClinicalTrials.gov registry entry for NCT06742723 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 5,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Chronic Kidney Disease and Hypertension appearing as the primary indexed condition, and to 2 interventions — of which Baxdrostat/dapagliflozin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06742723 reports 20 study locations spanning 7 distinct geographic areas — top geographies include California, Arizona, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06742723 about?

NCT06742723 is a clinical study titled "A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure". International, Multicenter, Double-Blind, Placebo-Controlled and Event-driven study to assess efficacy, safety and Tolerability of Baxdrostat in combination with Dapagliflozin on renal outcomes and cardiovascular mortality in participants with chronic kidney disease and high blood pressure

What is the current status of trial NCT06742723?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 5,000 participants. The study started on 2025-03-03. Estimated completion is 2029-12-18.

What conditions does trial NCT06742723 study?

This clinical trial studies the following conditions: Chronic Kidney Disease and Hypertension. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06742723?

The interventions under investigation include: Baxdrostat/dapagliflozin (DRUG), Placebo/dapagliflozin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06742723?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06742723 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial