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NCT06660225 · ClinicalTrials.gov registry record · NA
Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder
A NA study, sponsored by Nader Pouratian.
- Recruiting
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT06660225: Recruiting NA study, sponsored by Nader Pouratian.
NCT06660225 is a NA study that is actively recruiting participants, run by Nader Pouratian. The registered enrollment target is 10 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06660225, a NA study, is actively recruiting participants, sponsored by Nader Pouratian.
- RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD). The main questions it aims to answer are: * Assess the effects of the anteromedial sub-thalamic nucleus (amSTN)stimulation on obsessive/compulsive symptoms. * Map the amSTN using neuronal responses \[single unit and local field potentials (LFP) recordings\] at rest and under high frequency stimulation during surgery. * Record chronic brain activity with the implanted pulse generator and look for neuronal signatures correlated with symptom severity. Researchers will compare active deep brain stimulation to a placebo (sham stimulation) to see if DBS works to treat refractory OCD. Participants will: * Undergo surgery for the implantation of a deep brain stimulation device * Follow-up visits every three weeks with study staff * 6 month follow-up for the next 2-3 years after first year of study participation is complete
Primary Outcome
Assessment of the efficacy of amSTN stimulation on OCD symptoms. This will be assessed by the Yale-Brown Obsessive-Compulsive Scale (YBOCS). Possible scores range from 0-5 where lower scores indicate better outcome.
Interventions
- DEVICE Medtronic Percept Deep Brain Stimulation Therapy [Sham Control Stimulation]
- DEVICE Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2026-06 |
| Est. Completion | 2031-01 |
| Phase | NA |
What NCT06660225 shows while recruiting
NCT06660225 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Medtronic Percept Deep Brain Stimulation Therapy [Sham Control Stimulation] is the first listed.
NCT06660225 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06660225 about?
NCT06660225 is a clinical study titled "Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder". The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD). The main questions it aims to answer are: * Assess the effects of the anteromedial sub-thalamic nucleus (amSTN)stimulation on obsessive/compulsive symptoms. * M...
What is the current status of trial NCT06660225?
This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2026-06. Estimated completion is 2031-01.
What interventions are being tested in trial NCT06660225?
The interventions under investigation include: Medtronic Percept Deep Brain Stimulation Therapy [Sham Control Stimulation] (DEVICE), Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation] (DEVICE).
Who is sponsoring clinical trial NCT06660225?
This trial is sponsored by Nader Pouratian, which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06660225's enrollment target sits among peer trials
10 1927th of 2000 higher than 26 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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